Evidence map›Paper›PMID 35566536›Full record

ArticleJournal of clinical medicine2022

Fatigue Is a Major Symptom at COVID-19 Hospitalization Follow-Up.

Søren Sperling, Andreas Fløe, Steffen Leth, Charlotte Hyldgaard, Tina Gissel, Ayfer Topcu, Lars Kristensen, Lene Dahl Sønderskov, Johannes Martin Schmid, Søren Jensen-Fangel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  4. Observational
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  7. Article
  8. Anxiety in Patients with Post-COVID Syndrome: Associated Factors.Psychology research and behavior management · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Søren SperlingDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, 8200 Aarhus, Denmark.ORCID 0000-0001-5700-3948
Andreas FløeDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, 8200 Aarhus, Denmark.
Steffen LethDepartment of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
Charlotte HyldgaardDiagnostic Centre, Silkeborg Regional Hospital, 8600 Silkeborg, Denmark.ORCID 0000-0002-6353-8671
Tina GisselDepartment of Respiratory Diseases, Viborg Regional Hospital, 8800 Viborg, Denmark.
Ayfer TopcuDepartment of Respiratory Diseases, Horsens Regional Hospital, 8700 Horsens, Denmark.
Lars KristensenDepartment of Respiratory Diseases, Regional Hospital West Jutland, 7400 Goedstrup, Denmark.
Lene Dahl SønderskovDepartment of Respiratory Diseases, Randers Regional Hospital, 8900 Randers, Denmark.
Johannes Martin SchmidDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, 8200 Aarhus, Denmark.
Søren Jensen-FangelDepartment of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
Elisabeth BendstrupDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, 8200 Aarhus, Denmark.
Aarhus University · DKAarhus University Hospital · DKRegional Hospital Horsens · DKRegional Hospital Randers · DKRegional Hospital West Jutland · DKRegionshospitalet Silkeborg · DKRegionshospitalet Viborg · DK

Funding

Novo Nordisk Foundation NNF21OC0066984
6 · The paper itself

Abstract

Persistent symptoms after hospitalization with COVID-19 are common, but the frequency and severity of these symptoms are insufficiently understood. We aimed to describe symptoms and pulmonary function after hospitalization with COVID-19. Patients hospitalized with COVID-19 in Central Denmark Region were invited for follow-up 3 months after discharge. Clinical characteristics, patient reported outcomes (Fatigue Assessment Scale (FAS), anxiety and depression (HADS)), symptoms, pulmonary function test and 6-min walk test were collected. We included 218 patients (mean age 59.9 (95% CI: 58.2, 61.7), 59% males). Fatigue, dyspnea and impaired concentration were the most prevalent symptoms at follow-up. Using FAS, 47% reported mild-to-moderate fatigue and 18% severe fatigue. Mean HADS was 7.9 (95% CI: 6.9, 8.9). FAS was correlated to HADS (β = 0.52 (95% CI: 0.44, 0.59, p < 0.001)). Mean DLCO was 80.4% (95% CI: 77.8, 83.0) and 45% had DLCO ˂ 80%. Mean DLCO was significantly reduced in patients treated in the ICU (70.46% (95% CI 65.13, 75.79)). The highest FAS and HADS were seen in patients with the shortest period of hospitalization (2.1 days (95% CI: 1.4, 2.7)) with no need for oxygen. In conclusion, fatigue is a common symptom after hospitalization for COVID-19 and ICU treatment is associated to decreased diffusion capacity.

Indexed as

COVID-19fatiguelong COVIDpulmonary function

Identifiers

PMID35566536
PMCPMC9106038
OpenAlexW4224442733

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.