Evidence map›Paper›PMID 35566535›Full record

ArticleJournal of clinical medicine2022

A Disseminated Mycobacterium Abscessus Infection in a Patient Affected by Pulmonary Graft versus Host Disease: Case Report with a Revision of Literature.

Andrea Bernardelli, Alberto Schena, Alessia Savoldi, Chiara Colato, Valentina Baretta, Emiliano D'Alessandro, Giulia Zamboni, Mehrdad Shoushtari Zadeh Naseri, Flavio Favaro, Marta Peracchi and 4 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Andrea BernardelliSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, Verona University, 37134 Verona, Italy.
Alberto SchenaSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, Verona University, 37134 Verona, Italy.
Alessia SavoldiInfectious Diseases Unit, Department of Diagnostics and Public Health, Verona University, 37134 Verona, Italy.
Chiara ColatoSection of Pathology, Verona University, 37134 Verona, Italy.
Valentina BarettaSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, Verona University, 37134 Verona, Italy.
Emiliano D'AlessandroSection of Pathology, Verona University, 37134 Verona, Italy.
Giulia ZamboniDepartment of Radiology, Verona University, 37134 Verona, Italy.
Mehrdad Shoushtari Zadeh NaseriDepartment of Nuclear Medicine, Verona University, 37134 Verona, Italy.
Flavio FavaroSection of Microbiology, Department of Diagnostics and Public Health, Verona University, 37134 Verona, Italy.
Marta PeracchiMicrobiology and Virology Unit, Padua University, 35122 Padova, Italy.
Donatella SchenaSection of Dermatology and Venereology, Department of Medicine, Verona University, 37134 Verona, Italy.
Angelo AndreiniSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, Verona University, 37134 Verona, Italy.
Simone CesaroPediatric Hematology Oncology, Verona University Hospital, 37134 Verona, Italy.ORCID 0000-0002-8698-9547
Cristina TecchioSection of Hematology and Bone Marrow Transplant Unit, Department of Medicine, Verona University, 37134 Verona, Italy.ORCID 0000-0002-4001-1607
University of Verona · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium abscessus complex, hereinafter Mab, is a taxonomic group of rapidly growing, nontuberculous mycobacteria (NTM). Despite major advances in understanding virulence, pathogenicity and mechanism of antibiotic resistance, Mab remains a significant cause of pulmonary and extra-pulmonary disease. Herein, we describe a disseminated, macrolide-resistant, Mab subspecies abscessus infection occurring in a severely immune-compromised 34-year-old allotransplanted female patient affected by pulmonary chronic graft versus host disease (cGVHD). The infection was characterized by hematogenous spread, and besides lungs, it involved skin, and soft tissues, resulting in a highly debilitating, painful, and finally fatal disease. Our case describes the severe impact of Mab infections in the setting of allogeneic hematopoietic stem cells transplant (alloHSCT) and related complications. It also highlights the unmet need of preventive and surveillance measures together with the urgency of developing effective vaccines and drugs against emerging NTM. The scarce literature regarding Mab infections in alloHSCT patients is also reviewed.

Indexed as

haploidentical hematopoietic stem cell transplantMycobacterium abscessus complexnontuberculous mycobacteriapulmonary chronic graft versus host disease

Identifiers

PMID35566535
PMCPMC9101786
OpenAlexW4224859090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.