ReviewJournal of clinical medicine2022
Treatment of Mandibular Hypomobility by Injections into the Temporomandibular Joints: A Systematic Review of the Substances Used.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Pooled it
- Injection of Adipose-Derived Mesenchymal Stem Cell-Enriched Adipose Extract for Temporomandibular Joint Osteoarthritis: A Randomised Controlled Trial.International dental journal · 2026Trial
- Trial
- Dextrose prolotherapyeffectin improving thetemporomandibular joint disc displacement symptoms without reduction refractory to conservative treatment: a pilot study.Scientific reports · 2025Trial
- Baseline Oral Behaviours in Relation to Follow-Up Temporomandibular Joint Disease Severity After Intra-Articular I-PRF: A Baseline-Adjusted Exploratory Cohort Study.Journal of clinical medicine · 2026Article
- Effects of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) on Mandibular Mobility in Temporomandibular Joint Disorders: A Controlled Clinical Trial.Biomolecules · 2024Article
- Non-Steroidal Anti-Inflammatory Drugs Administered Intra-Articularly in Temporomandibular Joint Disorders: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Update on Evidence and Directions in Temporomandibular Joint Injection Techniques: A Rapid Review of Primary Research.Journal of clinical medicine · 2024Review
- Temporomandibular Disorders Management-What's New? A Scoping Review.Dentistry journal · 2024Article
- Temporomandibular Joint Injections and Lavage: An Overview of Reviews.Journal of clinical medicine · 2024Review
- A Comprehensive Analysis of the Efficacy of Injectable Medications in Relieving Temporomandibular Joint Discomfort: A Systematic Review.Journal of clinical practice and research · 2024Review
- Intra-Articular Local Anesthetics in Temporomandibular Disorders: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Autologous Blood Injections in Temporomandibular Hypermobility: A Systematic Review.Journal of clinical medicine · 2023Review
- Temporomandibular Joint Disorders: Functional and Conservative Treatment.Journal of clinical medicine · 2023Article
- Current Clinical Research Directions on Temporomandibular Joint Intra-Articular Injections: A Mapping Review.Journal of clinical medicine · 2023Review
- State of the Art in Temporomandibular Joint Arthrocentesis-A Systematic Review.Journal of clinical medicine · 2023Review
- Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review.Journal of clinical medicine · 2023Article
- Intra-Articular Injections into the Inferior versus Superior Compartment of the Temporomandibular Joint: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Effects of joint irrigation combined with ozone injection on bone metabolism, inflammatory factors, and joint function in knee osteoarthritis.American journal of translational research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHyaluronic acid, steroids and blood products are popularly injected into the temporomandibular joint (TMJs) to relieve pain and increase the extent of mandibular abduction. The purpose of this review is to identify other injectable substances and to evaluate them in the above-mentioned domains. MATERIAL AND
methodsThe review included articles describing clinical trials of patients treated with intra-articular injections with or without arthrocentesis.
resultsThe following emerging substances were initially evaluated to be effective in treating TMJ pain and increasing the amplitude of mandibular abduction: analgesics, dextrose with lidocaine, adipose tissue, nucleated bone marrow cells and ozone gas. DISCUSSION: Better effects of intra-articular administration are achieved by preceding the injection with arthrocentesis.
conclusionsThe most promising substances appear to be bone marrow and adipose tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.