Evidence map›Paper›PMID 35566386›Full record

ArticleMolecules (Basel, Switzerland)2022

Antifungal Activity and In Silico Studies on 2-Acylated Benzo- and Naphthohydroquinones.

David Ríos, Jaime A Valderrama, Gonzalo Quiroga, Jonathan Michea, Felipe Salas, Eduardo Álvarez Duarte, Edmundo A Venegas-Casanova, Rafael Jara-Aguilar, Carlos Navarro-Retamal, Pedro Buc Calderon and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

David RíosQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Jaime A ValderramaQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Gonzalo QuirogaQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Jonathan MicheaQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Felipe SalasQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0003-3598-7485
Eduardo Álvarez DuarteUnidad de Micología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile.ORCID 0000-0001-6117-7916
Edmundo A Venegas-CasanovaFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Rafael Jara-AguilarFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Carlos Navarro-RetamalInstituto de Ciencias Biológicas, Universidad de Talca, 2 Norte 685, Talca 3460000, Chile.ORCID 0000-0001-9581-0206
Pedro Buc CalderonQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Julio BenitesQuímica y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0002-8562-0078
Arturo Prat University · CLNational University of Trujillo · PEUniversity of Chile · CLUniversity of Talca · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to the several resemblances between fungal and human cells. Here, we report the in vitro antifungal evaluation of two acylphenols series, namely 2-acyl-1,4-benzo- and 2-acyl-1,4-naphthohydroquinones. The antifungal properties were assessed on diverse

Indexed as

Antifungal AgentsMycosesAmphotericin BCandidaFungiHumansMicrobial Sensitivity TestsMolecular Docking SimulationAmphotericin BAntifungal Agentsacylhydroquinonesantifungal activityCandidafilamentous fungi

Identifiers

PMID35566386
PMCPMC9103303
OpenAlexW4229451702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.