Evidence map›Paper›PMID 35566381›Full record

ArticleMolecules (Basel, Switzerland)2022

A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin

Alica Fischle, Rico Schwarz, Franziska Wendt, Marcel Kordt, Robert Ramer, Lars Boeckmann, Martin Hein, Peter Langer, Steffen Emmert, Brigitte Vollmar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Beilstein journal of organic chemistry · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alica FischleInstitute of Pharmacology and Toxicology, Rostock University Medical Center, 18057 Rostock, Germany.
Rico SchwarzInstitute of Pharmacology and Toxicology, Rostock University Medical Center, 18057 Rostock, Germany.
Franziska WendtInstitute of Pharmacology and Toxicology, Rostock University Medical Center, 18057 Rostock, Germany.
Marcel KordtRudolf Zenker Institute for Experimental Surgery, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-5826-1217
Robert RamerInstitute of Pharmacology and Toxicology, Rostock University Medical Center, 18057 Rostock, Germany.
Lars BoeckmannClinic and Policlinic for Dermatology, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0003-0098-6546
Martin HeinInstitute of Organic Chemistry, University of Rostock, 18059 Rostock, Germany.
Peter LangerInstitute of Organic Chemistry, University of Rostock, 18059 Rostock, Germany.
Steffen EmmertClinic and Policlinic for Dermatology, Rostock University Medical Center, 18057 Rostock, Germany.
Brigitte VollmarRudolf Zenker Institute for Experimental Surgery, Rostock University Medical Center, 18057 Rostock, Germany.
Burkhard HinzInstitute of Pharmacology and Toxicology, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0000-0002-2529-0732
University of Rostock · DE

Funding

European Social Fund, reference: ESF/14-BM-A55-0002/18, and the Ministry of Education, Science and Culture of Mecklenburg-Vorpommern, Germany. reference: ESF/14-BM-A55-0002/18
6 · The paper itself

Abstract

Indirubin was identified as an active component of Danggui Longhui Wan, an herbal mixture used in traditional Chinese medicine, and showed anticancer activity in clinical trials in patients with chronic leukemia. Investigations on the mechanisms of antitumor action of indirubins have mainly focused on the indirubin derivative indirubin-3'-monoxime (I3M). Meanwhile, antiproliferative and cytotoxic properties on cancer cells have also been demonstrated for several synthetic indirubin

Indexed as

Antineoplastic AgentsGlycosidesAnimalsCell Culture TechniquesChromatography, LiquidHumansIndolesMiceOximesOxindolesReproducibility of ResultsTandem Mass SpectrometryAntineoplastic AgentsGlycosidesindirubinindirubin-3'-monoximeIndolesOximesOxindolesLC-MS/MSliquid-liquid extractionprotein precipitationthia-analogous indirubin N-glycosidesvalidation

Identifiers

PMID35566381
PMCPMC9101087
OpenAlexW4229460482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.