ArticleMolecules (Basel, Switzerland)2022
Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 26 citations in OpenAlex.
- The Importance of Stereochemistry in 5-HTACS chemical neuroscience · 2024Article
- Review of Applications of β-Cyclodextrin as a Chiral Selector for Effective Enantioseparation.International journal of molecular sciences · 2024Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccharide-type chiral stationary phase (CSP). In the screening phase of method development, seven columns were tested in polar organic (PO) mode using mobile phases consisting of 0.1% acetic acid in methanol, ethanol, 2-propanol, and acetonitrile. Enantiorecognition was observed only in five cases. The best enantioseparation was observed on a Lux Amylose-1 column with 0.1% (
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Registered trials
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