Evidence map›Paper›PMID 35566311›Full record

ArticleMolecules (Basel, Switzerland)2022

Proliferation and Invasion of Melanoma Are Suppressed by a Plant Protease Inhibitor, Leading to Downregulation of Survival/Death-Related Proteins.

Camila Ramalho Bonturi, Bruno Ramos Salu, Camila Nimri Bonazza, Rita de Cassia Sinigaglia, Tiago Rodrigues, Miryam Paola Alvarez-Flores, Ana Marisa Chudzinski-Tavassi, Maria Luiza Vilela Oliva

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Camila Ramalho BonturiDepartamento de Bioquímica, Universidade Federal de São Paulo (UNIFESP), São Paulo 04044-020, Brazil.ORCID 0000-0001-9324-8424
Bruno Ramos SaluDepartamento de Bioquímica, Universidade Federal de São Paulo (UNIFESP), São Paulo 04044-020, Brazil.
Camila Nimri BonazzaDepartamento de Bioquímica, Universidade Federal de São Paulo (UNIFESP), São Paulo 04044-020, Brazil.
Rita de Cassia SinigagliaElectron Microscopy Center, Universidade Federal de São Paulo (UNIFESP), São Paulo 04044-020, Brazil.
Tiago RodriguesCentre for Natural and Human Sciences, Universidade Federal do ABC (UFABC), Santo André 09210-580, Brazil.ORCID 0000-0003-1277-0224
Miryam Paola Alvarez-FloresCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-7986-923X
Ana Marisa Chudzinski-TavassiCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.
Maria Luiza Vilela OlivaDepartamento de Bioquímica, Universidade Federal de São Paulo (UNIFESP), São Paulo 04044-020, Brazil.ORCID 0000-0001-7346-6328
Universidade Federal de São Paulo · BRInstituto Butantan · BRUniversidade Federal do ABC · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001National Council for Scientific and Technological Development 301721/2016-5São Paulo Research Foundation 2017/06630-7 and 2019/22243-9
6 · The paper itself

Abstract

Cell adhesion and migration are crucial for cancer progression and malignancy. Drugs available for the treatment of metastatic melanoma are expensive and unfit for certain patients. Therefore, there is still a need to identify new drugs that block tumor cell development. We investigated the effects of

Indexed as

FabaceaeMelanomaApoptosisCell Line, TumorCell ProliferationDown-RegulationHumansNeoplastic ProcessesProtease InhibitorsTrypsin InhibitorsProtease InhibitorsTrypsin InhibitorsEcTImelanomametastasisprotease inhibitorskin cancer

Identifiers

PMID35566311
PMCPMC9104945
OpenAlexW4229011286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.