Evidence map›Paper›PMID 35566308›Full record

ArticleMolecules (Basel, Switzerland)2022

Investigating the Stability of Six Phenolic TMZ Ester Analogues, Incubated in the Presence of Porcine Liver Esterase and Monitored by HPLC.

Leroy A Shervington, Oliver Ingham

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leroy A ShervingtonSchool of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
Oliver InghamKindeva Drug Delivery, Bakewell Road, Loughborough LE11 5RB, UK.
University of Central Lancashire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous published data from our group showed the encouraging in vitro activities of six phenolic temozolomide (TMZ) ester analogues (ES8-ES12 and ES14) with up to a five-fold increase in potency compared to TMZ against glioblastoma multiform cell lines and TMZ-resistant O

Indexed as

Brain NeoplasmsGlioblastomaAnimalsAntineoplastic Agents, AlkylatingCell Line, TumorChromatography, High Pressure LiquidDNA Modification MethylasesDNA Repair EnzymesDrug Resistance, NeoplasmEsterasesEstersLiverSwineTemozolomideTumor Suppressor ProteinsAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesEsterasesEstersTemozolomideTumor Suppressor Proteinsdiode-array detector (DAD)glioblastoma multiform (GBM)high-performance liquid chromatography (HPLC)hydrolysisphenolic TMZ estersporcine liver esterase (PLE)stabilitytemozolomide (TMZ)

Identifiers

PMID35566308
PMCPMC9103334
OpenAlexW4229006407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.