Evidence map›Paper›PMID 35566306›Full record

ArticleMolecules (Basel, Switzerland)2022

Solvent Casting and UV Photocuring for Easy and Safe Fabrication of Nanocomposite Film Dressings.

Laura Di Muzio, Prisca Simonetti, Vito Cosimo Carriero, Chiara Brandelli, Jordan Trilli, Claudia Sergi, Jacopo Tirillò, Francesco Cairone, Stefania Cesa, Giulia Radocchia and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Laura Di MuzioDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Prisca SimonettiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Vito Cosimo CarrieroDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Chiara BrandelliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Jordan TrilliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Claudia SergiDepartment of Chemical Engineering Materials Environment, Sapienza University of Rome, 00184 Rome, Italy.
Jacopo TirillòDepartment of Chemical Engineering Materials Environment, Sapienza University of Rome, 00184 Rome, Italy.ORCID 0000-0001-5734-7396
Francesco CaironeDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-9618-1410
Stefania CesaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-8649-0017
Giulia RadocchiaDepartment of Public Health and Infection Disease, Microbiology Section, Sapienza University of Rome, 00185 Rome, Italy.
Serena SchippaDepartment of Public Health and Infection Disease, Microbiology Section, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1572-2623
Stefania PetralitoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.
Patrizia PaolicelliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-3941-2355
Maria Antonietta CasadeiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-8414-3273
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work was to optimize and characterize nanocomposite films based on gellan gum methacrylate (GG-MA) and silver nanoparticles (AgNPs) for application in the field of wound dressing. The films were produced using the solvent casting technique coupled with a photocuring process. The UV irradiation of GG-MA solutions containing glycerol as a plasticizer and different amounts of silver nitrate resulted in the concurrent crosslinking of the photocurable polymer and a reduction of Ag ions with consequent in situ generation of AgNPs. In the first part of the work, the composition of the films was optimized, varying the concentration of the different components, the GG-MA/glycerol and GG-MA/silver nitrate weight ratios as well as the volume of the film-forming mixture. Rheological analyses were performed on the starting solutions, whereas the obtained films were characterized for their mechanical properties. Colorimetric analyses and swelling studies were also performed in order to determine the AgNPs release and the water uptake capacity of the films. Finally, microbiological tests were carried out to evaluate the antimicrobial efficacy of the optimized films, in order to demonstrate their possible application as dressings for the treatment of infected hard-to-heal wounds, which is a demanding task for public healthcare.

Indexed as

Metal NanoparticlesNanocompositesAnti-Bacterial AgentsBandagesGlycerolSilverSilver NitrateSolventsAnti-Bacterial AgentsGlycerolSilverSilver NitrateSolventsantimicrobial activitycolorimetrygellan gum methacrylatephotocuringsilver nanoparticlessolvent castingthin filmwound dressings

Identifiers

PMID35566306
PMCPMC9102005
OpenAlexW4229059574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.