Evidence map›Paper›PMID 35566282›Full record

ArticleMolecules (Basel, Switzerland)2022

Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats.

Xinzhang Chen, Zhiheng Zhang, Meilun Shen, Xiangying Ma, Di Qiu, Siyao Li, Li Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xinzhang ChenCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Zhiheng ZhangCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Meilun ShenCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Xiangying MaCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Di QiuCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Siyao LiCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Li GaoCollege of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Northeast Agricultural University · CN

Funding

National Key R&D Program of China 2017YFD0501601-2National Natural Science Foundation of China 31372491National Natural Science Foundation of China 31572580
6 · The paper itself

Abstract

Ketamine is an anesthetic drug that is widely used in human and veterinary medicine. In the developmental stage, long-term exposure to ketamine may cause serious side effects. MCC950 and VX765 play protective roles in many disease models by regulating the NLRP3/Caspase-1 pathway. This study aims to explore the potential protective effect of MCC950 and VX765 on ketamine-induced liver injury in neonatal rats and clarify its underlying mechanism. After administration of MCC950 and VX765 in a ketamine-induced liver injury rat model, liver function and inflammatory factors were determined, and immunohistochemistry and western blotting were performed. We found that ketamine caused liver injury in 7-day-old SD rats, decreased liver function indexes, and increased inflammation. MCC950 and VX765 effectively alleviated liver damage and inflammation, and downregulated the expression of proteins such as NLRP3, Caspase-1, and GSDMD-N. In summary, these results indicated that MCC950 and VX765 could have potential protective effects on ketamine-induced liver injury through inhibiting the NLRP3/Caspase-1 pathway.

Indexed as

Chemical and Drug Induced Liver Injury, ChronicKetamineAnimalsCaspase 1Disease Models, AnimalDown-RegulationInflammasomesInflammationNLR Family, Pyrin Domain-Containing 3 ProteinRatsRats, Sprague-DawleyCaspase 1InflammasomesKetamineNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratdeveloping ratsketamineliversNLRP3/Caspase-1

Identifiers

PMID35566282
PMCPMC9103672
OpenAlexW4229021035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.