Evidence map›Paper›PMID 35566258›Full record

ArticleMolecules (Basel, Switzerland)2022

Preparation of Antibacterial Gelatin/Genipin Nanofibrous Membrane for Tympanic Membrane Repair.

Shuying Han, Zhaohua Zhang, Jia Chen, Jie Li, Mi Zhou, Zejian He, Zhen He, Longfei Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shuying HanMaterial Science and Engineering, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310000, China.
Zhaohua ZhangMaterial Science and Engineering, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310000, China.
Jia ChenThe Department of Otolaryngology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China.
Jie LiResearch and Development Department, Hangzhou Singclean Medical Products Co., Ltd., Hangzhou 310000, China.
Mi ZhouMaterial Science and Engineering, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310000, China.ORCID 0000-0001-8588-878X
Zejian HeMaterial Science and Engineering, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310000, China.
Zhen HeMaterial Science and Engineering, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310000, China.
Longfei LiMaterial Science and Engineering, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310000, China.
Zhejiang University of Technology · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

The applied research project of public technology of Zhejiang province 2015C33215
6 · The paper itself

Abstract

Tympanic membrane perforation (TMP), a common disease, often needs a scaffold as the patch to support surgery. Due to the environment of auditory meatus, the patch can be infected by bacteria that results in failure; therefore, the ideal scaffold may combine biomimetic and antibacterial features. In this work, gelatin was used as the electrospinning framework, genipin as the crosslinking agent, and levofloxacin as an antibacterial in order to prepare the scaffold for TMP. Different contents of levofloxacin have been added to gelatin/genipin. It was found that, with the addition of levofloxacin, the gelatin/genipin membranes exhibit improved hydrophilia and enhanced tensile strength. The antibacterial and cell-cultured experiments showed that the prepared antibacterial membranes had excellent antibacterial properties and good biocompatibility, respectively. In summary, levofloxacin is a good group for the gelatin/genipin scaffold because it improves the physical properties and antibacterial action. Compared with different amounts of levofloxacin, a gelatin/genipin membrane with 1% levofloxacin is more suitable for a TM.

Indexed as

GelatinNanofibersAnti-Bacterial AgentsIridoidsLevofloxacinTissue ScaffoldsTympanic MembraneAnti-Bacterial AgentsGelatingenipinIridoidsLevofloxacingelatingenipinlevofloxacinnanofiber membranetympanic membrane

Identifiers

PMID35566258
PMCPMC9104484
OpenAlexW4225320098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.