Evidence map›Paper›PMID 35566201›Full record

ArticleMolecules (Basel, Switzerland)2022

Identification of Potential Anti-Neuroinflammatory Inhibitors from Antarctic Fungal Strain

Thao Quyen Cao, Zhiming Liu, Linsha Dong, Hwan Lee, Wonmin Ko, Le Ba Vinh, Nguyen Quoc Tuan, Youn-Chul Kim, Jae Hak Sohn, Joung Han Yim and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Inhibitory Effects ofAntioxidants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Thao Quyen CaoInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea.
Zhiming LiuCollege of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.
Linsha DongCollege of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.
Hwan LeeCollege of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.ORCID 0000-0001-5015-5949
Wonmin KoCollege of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.
Le Ba VinhInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea.ORCID 0000-0002-0564-2606
Nguyen Quoc TuanInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea.
Youn-Chul KimInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea.
Jae Hak SohnCollege of Medical and Life Sciences, Silla University, Busan 46958, Korea.
Joung Han YimDivision of Polar Life Sciences, Korea Polar Research Institute, Incheon 21990, Korea.
Dong-Sung LeeCollege of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.ORCID 0000-0002-9234-7567
Hyuncheol OhInstitute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea.
Chosun University · KRWonkwang University · KRKorea Polar Research Institute · KRSilla University · KR

Funding

This work was supported by a grant from the Ministry of Oceans and Fisheries' R&D project, Korea 2021633
6 · The paper itself

Abstract

Microglia play a significant role in immune defense and tissue repair in the central nervous system (CNS). Microglial activation and the resulting neuroinflammation play a key role in the pathogenesis of neurodegenerative disorders. Recently, inflammation reduction strategies in neurodegenerative diseases have attracted increasing attention. Herein, we discovered and evaluated the anti-neuroinflammatory potential of compounds from the Antarctic fungi strain

Indexed as

MicrogliaNF-kappa BAntarctic RegionsAnti-Inflammatory AgentsAspergillusInterleukin-6LipopolysaccharidesNitric OxideNitric Oxide Synthase Type IISignal TransductionSterigmatocystinTumor Necrosis Factor-alphaAnti-Inflammatory AgentsInterleukin-6LipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IISterigmatocystinTumor Necrosis Factor-alphaAntarcticaBV2 cellsfungi metabolitesneuroinflammationNF-κBsterigmatocystin

Identifiers

PMID35566201
PMCPMC9103959
OpenAlexW4225114885

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.