ReviewMolecules (Basel, Switzerland)2022
The Hypopigmentation Mechanism of Tyrosinase Inhibitory Peptides Derived from Food Proteins: An Overview.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- Enhancement of Anti-Melanogenic Activity ofMarine drugs · 2026Article
- Discovery of TYR inhibitors from de novo molecular generation to dual-track lead optimization: "Competition" between AI and chemists.Science advances · 2026Article
- Unraveling the Antimelanogenic Potential ofJournal of agricultural and food chemistry · 2026Article
- Unlocking Bioactive, Peptide-Rich Extracts from Tomato Seeds Using Enzymatic-Assisted Extraction.Foods (Basel, Switzerland) · 2026Article
- Tilapia Skin-Derived Peptide PFRMY Attenuates Melanogenesis and Tyrosinase Activity via α-MSH/PKA/CREB Signaling Pathways in B16F10 Murine Melanoma Cells.Foods (Basel, Switzerland) · 2026Article
- Preparation and Whitening Activity of Sialoglycopeptide of Chalaza from Liquid Egg Process.Molecules (Basel, Switzerland) · 2025Article
- Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2025Article
- Novel tyrosinase-inhibitory peptides derived fromFood chemistry: X · 2025Article
- Inhibition effects of Eucalyptus globules Labill. essential oil against tyrosinase.Scientific reports · 2025Article
- Research progress on pathogenesis of skin pigmentation in chronic liver disease.Biomolecules & biomedicine · 2025Review
- Advancing the accuracy of tyrosinase inhibitory peptides prediction via a multiview feature fusion strategy.Scientific reports · 2025Article
- Unveiling the Phytochemical Diversity and Bioactivity ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Medicinal Plants in the Treatment of Respiratory Diseases and their Future Aspects.Recent patents on biotechnology · 2025Review
- Article
- Bee pollen peptides as potent tyrosinase inhibitors with anti-melanogenesis effects in murine b16f10 melanoma cells and zebrafish embryos.Scientific reports · 2024Article
- Copper and Colorectal Cancer.Cancers · 2024Review
- Discovery of superior bioactive peptides of two edibleFood science and biotechnology · 2024Article
- In Silico Identification and Molecular Mechanism of Novel Tyrosinase Inhibitory Peptides Derived from Nacre ofMarine drugs · 2024Article
- Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Design, synthesis,Heliyon · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin hyperpigmentation resulting from excessive tyrosinase expression has long been a problem for beauty lovers, which has not yet been completely solved. Although researchers are working on finding effective tyrosinase inhibitors, most of them are restricted, due to cell mutation and cytotoxicity. Therefore, functional foods are developing rapidly for their good biocompatibility. Food-derived peptides have been proven to display excellent anti-tyrosinase activity, and the mechanisms involved mainly include inhibition of oxidation, occupation of tyrosinase's bioactive site and regulation of related gene expression. For anti-oxidation, peptides can interrupt the oxidative reactions catalyzed by tyrosinase or activate an enzyme system, including SOD, CAT, and GSH-Px to scavenge free radicals that stimulate tyrosinase. In addition, researchers predict that peptides probably occupy the site of the substrate by chelating with copper ions or combining with surrounding amino acid residues, ultimately inhibiting the catalytic activity of tyrosinase. More importantly, peptides reduce the tyrosinase expression content, primarily through the cAMP/PKA/CREB pathway, with PI3K/AKT/GSK3β, MEK/ERK/MITF and p38 MAPK/CREB/MITF as side pathways. The objective of this overview is to recap three main mechanisms for peptides to inhibit tyrosinase and the emerging bioinformatic technologies used in developing new inhibitors.
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