Evidence map›Paper›PMID 35566055›Full record

ReviewMolecules (Basel, Switzerland)2022

Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents.

Tuyen N Tran, Maged Henary

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Recent Advances in Nitrogen-Containing Heterocyclic Scaffolds as Antiviral Agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Microwave-Induced Synthesis of Bioactive Nitrogen Heterocycles.Current topics in medicinal chemistry · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Molecules (Basel, Switzerland) · 2024
    Review
  14. Discovery of Pyrano[2,3-Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tuyen N TranDepartment of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA.ORCID 0000-0002-4747-8349
Maged HenaryDepartment of Chemistry, Georgia State University, 100 Piedmont Avenue SE, Atlanta, GA 30303, USA.ORCID 0000-0002-6475-0156
Georgia State University · US

Funding

National Institute of Health T34GM131939
6 · The paper itself

Abstract

Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence of new viruses and subject to drug resistance. Nitrogen-containing heterocycles have compatible structures and properties with exceptional biological activity for the drug design of antiviral agents. They provided a broad spectrum of interference against viral infection at various stages, from blocking early viral entry to disrupting the viral genome replication process by targeting different enzymes and proteins of viruses. This review focused on the synthesis and application of antiviral agents derived from various nitrogen-containing heterocycles, such as indole, pyrrole, pyrimidine, pyrazole, and quinoline, within the last ten years. The synthesized scaffolds target HIV, HCV/HBV, VZV/HSV, SARS-CoV, COVID-19, and influenza viruses.

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentHumansNitrogenSARS-CoV-2Virus ReplicationAntiviral AgentsNitrogenantiviral agentsCOVID-19inhibitionnitrogen-containing heterocyclessynthesisviruses

Identifiers

PMID35566055
PMCPMC9101374
OpenAlexW4224319036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.