Evidence map›Paper›PMID 35566035›Full record

ReviewMolecules (Basel, Switzerland)2022

Pathophysiological Role and Medicinal Chemistry of A

Stefania Merighi, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi, Alessia Travagli, Manuela Nigro, Silvia Pasquini, R Rama Suresh, Sung Won Kim, Nora D Volkow and 2 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.Journal of cellular and molecular medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Radiosynthesis and In Vitro Evaluation of [Molecules (Basel, Switzerland) · 2024
    Article
  8. Review
  9. Review
  10. AInternational review of neurobiology · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Stefania MerighiDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0839-6671
Pier Andrea BoreaDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Katia VaraniDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-4562-1348
Fabrizio VincenziDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-5027-1699
Alessia TravagliDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
Manuela NigroDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
Silvia PasquiniDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-9442-1428
R Rama SureshMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0001-7693-3681
Sung Won KimLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Nora D VolkowLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA.ORCID 0000-0001-8104-1493
Stefania GessiDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
University of Ferrara · ITNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · US

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
NIDDK Intramural Res. Program. University of Ferrara ZIADK031117,K.A.J.; Y1AA-3009, N.D.V.University of Ferrara FIR 2017
6 · The paper itself

Abstract

The A

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsChemistry, PharmaceuticalHippocampusHumansPurinergic P1 Receptor AntagonistsReceptor, Adenosine A2AAmyloid beta-PeptidesPurinergic P1 Receptor AntagonistsReceptor, Adenosine A2AA2A antagonist discoveryA2A receptorsAlzheimer’s diseasememory lossneurodegeneration

Identifiers

PMID35566035
PMCPMC9102440
OpenAlexW4224313593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.