Evidence map›Paper›PMID 35565996›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators.

George Papageorgiou, John E T Corrie

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

George PapageorgiouChemical Biology STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-8960-5836
John E T CorrieMRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Funding

THE CONTRACTILE SYSTEM OF VASCULAR SMOOTH MUSCLEP01HL019242 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI OWENS, GARY K · 1985 to 2009
$16.9M
NHLBI NIH HHS P01 HL019242Wellcome Trust FC001029Wellcome Trust FC001066Wellcome Trust FC001999
6 · The paper itself

Abstract

Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.

Indexed as

CalciumChelating AgentsAmino AcidsCalcium Chelating AgentsIonsPhotolysisAmino AcidsCalciumCalcium Chelating AgentsChelating AgentsIonscalcium chelatorschemical synthesisnitroindoline cagesphotolysisphotostability

Identifiers

PMID35565996
PMCPMC9104977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.