Evidence map›Paper›PMID 35565856›Full record

ArticleNutrients2022

Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey.

Antonella Lezo, Antonella Diamanti, Evelyne M Marinier, Merit Tabbers, Anat Guz-Mark, Paolo Gandullia, Maria I Spagnuolo, Sue Protheroe, Noel Peretti, Laura Merras-Salmio and 20 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Review of nutrition management of pediatric intestinal pseudo-obstruction.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  3. Playing sport as a central-line carrier: a survey to collect the European pediatric intestinal failure centers' view.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Article
  4. Article
  5. Review
  6. The Development of the International Intestinal Failure Registry and an Overview of its Results.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 12 countries.

Antonella LezoDepartment of Clinical Nutrition, OIRM-S, Anna Hospital, Città della Salute e della Scienza, 10126 Turin, Italy.
Antonella DiamantiOspedale Bambin Gesù, 00165 Rome, Italy.
Evelyne M MarinierService des Maladies Digestives et Respiratoires de l'Enfant, Centre de Référence des Maladies Digestives Rares, Hôpital R Debré, 75019 Paris, France.
Merit TabbersEmma Children's Hospital/Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.
Anat Guz-MarkInstitute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva 4920235, Israel.ORCID 0000-0003-4175-7432
Paolo GandulliaPediatric Gastroenterology and Endoscopy, IRCCS G, Gaslini Institute, 16147 Genoa, Italy.ORCID 0000-0002-7901-4995
Maria I SpagnuoloSection of Paediatrics, Department of Translational Medical Science, University of Naples Federico II, 80138 Naples, Italy.ORCID 0000-0001-5396-4944
Sue ProtheroeDepartment of Gastroenterology and Nutrition, Birmingham Children's Hospital NHS Trust, Birmingham B4 6NH, UK.
Noel PerettiPaediatric Hospital "Femme Mère Enfant de Lyon", 69677 Lyon, France.ORCID 0000-0002-8359-5163
Laura Merras-SalmioPediatric Gastroenterology Unit, Helsinki University Hospital, Children's Hospital Helsinki, 00290 Helsinki, Finland.
Jessie M HulstErasmus Medical Center, Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands.
Sanja KolačekChildren's Hospital Zagreb, Zagreb Medical University, 10000 Zagreb, Croatia.
Looi C EeQueensland Children's Hospital, Brisbane, QLD 4101, Australia.ORCID 0000-0001-7532-0541
Joanna LawrenceRoyal Children's Hospital, Parkville, VIC 3052, Australia.
Jonathan HindPaediatric Liver, GI and Nutrition Centre, King's College Hospital, London SE5 9RS, UK.ORCID 0000-0001-9839-4797
Lorenzo D'AntigaPaediatric Hepatology, Gastroenterology and Transplantation, "Papa Giovanni XXIII" Hospital, 24127 Bergamo, Italy.ORCID 0000-0001-7150-3148
Giovanna VerlatoPaediatric Nutrition Service-Neonatal Intensive Care Unit, University Hospital of Padova, 35128 Padova, Italy.
Ieva PukiteUniversity Children Hospital, LV-1004 Riga, Latvia.ORCID 0000-0002-3318-2555
Grazia Di LeoPediatric Department, University of Trieste, IRCCS Burlo Garofolo, 34137 Trieste, Italy.
Tim VanuytselUniversity Hospital Leuven, Leuven Intestinal Failure and Transplantation (LIFT), 3000 Leuven, Belgium.ORCID 0000-0001-8728-0903
Maryana K Doitchinova-SimeonovaBulgarian Association of Patients with Malnutrition, 1233 Sofia, Bulgaria.ORCID 0000-0002-2500-9859
Lars EllegardSahlgrenska University Hospital, Institute of Medicine, Departement of Internal Medicine and Clinical Nutrition, University of Gothenburg, 41390 Gothenburg, Sweden.ORCID 0000-0002-2787-4336
Luisa MasconaleOspedale Orlandi, 37012 Bussolengo, Italy.
María Maíz-JiménezDepartment of Endocrinology and Nutrition, Hospital 12 de Octubre, 28041 Madrid, Spain.
Sheldon C CooperUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK.ORCID 0000-0003-3621-4345
Giorgia BrillantiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
Elena NardiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-4245-912X
Anna S SasdelliClinical Nutrition and Metabolism Unit, Center for Chronic Intestinal Failure, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bolohna, Italy.ORCID 0000-0001-9981-0086
Simon LalIntestinal Failure Unit, Salford Royal Foundation Trust, Salford M6 8HD, UK.
Loris PironiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-1773-8330
Azienda USL di Bologna · ITUniversity of Bologna · ITBirmingham Children's Hospital · GBChildren's Clinical University Hospital · LVChildren's Health Queensland Hospital and Health Service · AUChildren's Hospital Zagreb · HREmma Kinderziekenhuis · NLErasmus MC - Sophia Children’s Hospital · NLHelsinki University Hospital · FIHôpital Femme Mère Enfant · FRIstituto Giannina Gaslini · ITKing's College Hospital · GBKU Leuven · BEOspedale dei Bambini Vittore Buzzi · ITOspedale Papa Giovanni XXIII · ITResearch Institute Hospital 12 de Octubre · ESRoyal Children's Hospital · AUSahlgrenska University Hospital · SESalford Royal NHS Foundation Trust · GBTel Aviv University · IL

Funding

European Society for Clinical Nutrition and Metabolism not applicable
6 · The paper itself

Abstract

Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1−4 and 14−18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children.

Indexed as

Intestinal DiseasesIntestinal FailureParenteral Nutrition, HomeShort Bowel SyndromeAdultChildChronic DiseaseCross-Sectional StudiesFemaleHumansMalebody growthchildrenchronic intestinal failurehome parenteral nutritionintestinal transplantationintravenous supplementationtransition

Identifiers

PMID35565856
PMCPMC9103944
OpenAlexW4225273221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.