Evidence map›Paper›PMID 35565770›Full record

ReviewNutrients2022

Vitamin D as a Potential Player in Immunologic Control over Multiple Myeloma Cells: Implications for Adjuvant Therapies.

Piotr Kulig, Karolina Łuczkowska, Anna Bielikowicz, Debora Zdrojewska, Bartłomiej Baumert, Bogusław Machaliński

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Vitamin D and Multiple Myeloma: A Scoping Review.Current oncology (Toronto, Ont.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Piotr KuligDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-8695-8863
Karolina ŁuczkowskaDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0003-4008-7473
Anna BielikowiczDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Debora ZdrojewskaDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Bartłomiej BaumertDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-9933-5844
Bogusław MachalińskiDepartment of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Pomeranian Medical University · PL

Funding

Ministry of Science and Higher Education, under the name "Regional Excellence Initiative" in 2019-2022 002/RID/2018/19
6 · The paper itself

Abstract

Multiple myeloma (MM) is a plasma cell malignancy with multifactorial etiology. One of the underlying mechanisms is immune system dysregulation. Immunotherapy is being widely introduced into various MM treatment protocols. Nevertheless, little is known about boosting the immune system with supportive treatment. Although classical actions of vitamin D (VD) are very well established, their non-classical actions related to the modulation of the immune system in MM are still a subject of ongoing research. In this literature review, we intend to summarize research conducted on VD and MM, both in vitro and in vivo, with particular emphasis on immune system modulation, the induction of the differentiation of malignant MM cells, synergic activity with anti-MM drugs, and MM-associated peripheral neuropathy.

Indexed as

Multiple MyelomaVitamin DCombined Modality TherapyHumansImmunotherapyVitaminsVitamin DVitaminsadjuvant therapyimmunomodulationmultiple myelomaperipheral neuropathyvitamin Dvitamin K

Identifiers

PMID35565770
PMCPMC9105067
OpenAlexW4224942250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.