Evidence map›Paper›PMID 35565768›Full record

Trial reportNutrients2022

Chronic Circadian Disruption and Sleep Restriction Influence Subjective Hunger, Appetite, and Food Preference.

Andrew W McHill, Joseph T Hull, Elizabeth B Klerman

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
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  14. Violence in Healthcare Workers Is Associated with Disordered Eating.International journal of environmental research and public health · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew W McHillSleep, Chronobiology, and Health Laboratory, School of Nursing, Oregon Health & Science University, 3455 SW US Veterans Hospital Rd., Portland, OR 97239, USA.ORCID 0000-0002-9428-6884
Joseph T HullDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Elizabeth B KlermanDivision of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Brigham and Women's Hospital · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 1991 to 2018
$23.1M
Testing Effects of Melatonin on Uterine Contractions in WomenR01HD107064 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2022 to 2025
$3.0M
Multi-scale modeling of sleep behaviors in social networksR01GM105018 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, KLERMAN, ELIZABETH B. · 2013 to 2017
$2.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD086392National Heart Lung and Blood Institute T32HL007901, K01HL146992, R56HL156948, K24HL105664, R01HL114088, R01HL128538,National Space Biomedical Research Institute HFP02802, HFP04201, HDP0006NCATS NIH HHS UL1 TR002369NIA NIH HHS P01AG009975NICHD NIH HHS R01 HD107064NIGMS NIH HHS R01GM105018
6 · The paper itself

Abstract

Chronic circadian disruption (CCD), such as occurs during rotating shiftwork, and insufficient sleep are each independently associated with poor health outcomes, including obesity and glucose intolerance. A potential mechanism for poor health is increased energy intake (i.e., eating), particularly during the circadian night, when the physiological response to energy intake is altered. However, the contributions of CCD and insufficient sleep to subjective hunger, appetite, food preference, and appetitive hormones are not clear. To disentangle the influences of these factors, we studied seventeen healthy young adults in a 32-day in-laboratory study designed to distribute sleep, wakefulness, and energy intake equally across all phases of the circadian cycle, thereby imposing CCD. Participants were randomized to the Control (1:2 sleep:wake ratio,

Indexed as

AppetiteHungerFood PreferencesGhrelinHumansSleepSleep DeprivationYoung AdultGhrelincircadian misalignmentghrelininsufficient sleepleptinshiftwork

Identifiers

PMID35565768
PMCPMC9105437
OpenAlexW4224937808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.