ArticleNutrients2022
Partial Hydrolyzed Protein as a Protein Source for Infant Feeding: Do or Don't?
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- Partially hydrolyzed cow's milk protein formula with an added prebiotic is well-tolerated, safe, and supports age-appropriate growth in healthy term infants through one year of age: DBRCT.BMC pediatrics · 2026Trial
- Trial
- Extensively hydrolyzed versus intact milk protein formula and risk of necrotizing enterocolitis: a meta-analysis.Frontiers in pediatrics · 2026Review
- Bibliometric Analysis of Cow's Milk Protein Allergy Research in the Past Two Decades.Journal of inflammation research · 2026Article
- [Quantitation of cow's milk allergen in hypoallergenic infant formulas using ultra-high performance liquid chromatography- tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- Sweetness Ratings of U.S. Infant Formulas.Nutrients · 2025Article
- Term infant formula macronutrient composition: An update for clinicians.Journal of pediatric gastroenterology and nutrition · 2025Review
- Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice.Frontiers in pediatrics · 2025Article
- Article
- Using a new human milk fortifier to optimize human milk feeding among very preterm and/or very low birth weight infants: a multicenter study in China.BMC pediatrics · 2024Article
- Editorial: Feeding difficulties in newborn infants and new approaches in practice.Frontiers in pediatrics · 2024Article
- Influence of Complexation with β- and γ-Cyclodextrin on Bioactivity of Whey and Colostrum Peptides.International journal of molecular sciences · 2023Article
- Preparation of Hypoallergenic Whey Protein Hydrolysate by a Mixture of Alcalase and Prozyme and Evaluation of Its Digestibility and Immunoregulatory Properties.Food science of animal resources · 2023Article
- The Relevance of Nutrition for Pediatric Allergy and Immunity.Nutrients · 2023Article
- Milk Fat Globules: 2024 Updates.Newborn (Clarksville, Md.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exclusive breastfeeding until the age of six months is the recommended feeding method for all infants. However, this is not possible for every infant. Therefore, a second choice of feeding, as close as possible to the gold standard, is needed. For historical reasons, this has been cow's-milk-based feeding. This paper discusses if this second-choice feeding method should contain intact protein or partially hydrolyzed proteins. The limited data available indicates that mother's milk is relatively rich in bioactive peptides. Whether partially hydrolyzed protein might be a protein source closer to human milk protein content than intact cow's milk needs further research. However, more research on protein and bioactive peptides in mother's milk should be a priority for future scientific development in this field. Results of such research will also provide an answer to the question of which option would be the best second choice for infant feeding if sufficient breast milk is not available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.