Evidence map›Paper›PMID 35565343›Full record

ArticleCancers2022

Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice.

Christina Bruss, Kerstin Kellner, Olaf Ortmann, Stephan Seitz, Gero Brockhoff, James A Hutchinson, Anja Kathrin Wege

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christina BrussDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Kerstin KellnerDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Olaf OrtmannDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Stephan SeitzDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.
Gero BrockhoffDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.ORCID 0000-0001-8398-8349
James A HutchinsonDepartment of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-1199-4210
Anja Kathrin WegeDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-8838-0532
University Hospital Regensburg · DE

Funding

German Cancer Aid 111536German research foundation BR 1873/11-1
6 · The paper itself

Abstract

"Humanized" mice have been widely used for the characterization of human cancer progression and as a powerful preclinical model. Standardization of multicolor phenotyping could help to identify immune cell patterns involved in checkpoint-related complications. Therefore, we applied established protocols for immune cell profiling to our humanized Patient-Derived Xenograft (hPDX) model. hPDX are characterized by the co-existence of a human immune system and a patient-derived tumor transplant. These mice possess a human-like immune system after CD34

Indexed as

breast cancerhematopoietic stem cells (HSC)humanized patient-derived xenograft (hPDX)humanized tumor mice (HTM)immunotherapymulticolor flow cytometry

Identifiers

PMID35565343
PMCPMC9103756
OpenAlexW4225128284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.