ArticleInternational journal of environmental research and public health2022
Multiple Medication Adherence and Related Outcomes in Community-Dwelling Older People on Chronic Polypharmacy: A Retrospective Cohort Study on Administrative Claims Data.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Adherence to pharmacological treatment in non-communicable chronic diseases in the Colombian population: Systematic review and meta-analysisBiomedica : revista del Instituto Nacional de Salud · 2023Pooled it
- A Critical View over the Newest Antidiabetic Molecules in Light of Efficacy-A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Systematic evaluation of medication adherence determinants across 137 active substances on population-level real-world health data.Communications medicine · 2026Article
- Use of Mobile Application for Improving Drug Compliance and Clinical Outcomes: A Randomized Controlled Trial.International journal of telemedicine and applications · 2026Article
- Risk Prediction of Major Adverse Cardiovascular Events Within One Year After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome: Machine Learning-Based Time-to-Event Analysis.JMIR medical informatics · 2025Observational
- [Latent profile types and influencing factors of medication adherence mechanisms among rural older adults with multiple chronic conditions].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Development Track of Compliance With Dual Antiplatelet Therapy and Analysis of Potential Categories in Patients With ACS After PCI.Reviews in cardiovascular medicine · 2025Article
- Article
- Evaluation of methods measuring medication adherence in patients with polypharmacy: a longitudinal and patient perspective.European journal of clinical pharmacology · 2024Article
- Inappropriate prescribing of drugs for peptic ulcer and gastro-esophageal reflux disease remains a matter of concern: Results from the LAPTOP-PPI cluster randomized trial.Frontiers in pharmacology · 2024Article
- Identifying and presenting key country-specific indicators related to medication adherence: a comprehensive study across European countries.Frontiers in pharmacology · 2024Article
- Identifying Predictors of Nursing Home Admission by Using Electronic Health Records and Administrative Data: Scoping Review.JMIR aging · 2023Article
- Appropriateness of the Prescription and Use of Medicines: An Old Concept but More Relevant than Ever.International journal of environmental research and public health · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poor medication adherence compromises treatment efficacy and adversely affects patients' clinical outcomes. This study aims to assess (1) multiple medication adherence to the most common drug classes chronically prescribed to older people, (2) the factors associated, and (3) the clinical outcomes. This retrospective cohort study included 122,655 community-dwelling patients aged 65-94 years old, newly exposed to chronic polypharmacy, and recorded in the Lombardy Region (northern Italy) administrative database from 2016 to 2018. Multiple medication adherence was assessed for drugs for diabetes, antithrombotics, antihypertensives, statins, and bisphosphonates, by calculating the daily polypharmacy possession ratio (DPPR). One-year mortality, nursing home, emergency department (ED), and hospital admission rates were calculated for 2019. The most prescribed drugs were antihypertensives (89.0%). The mean (std.dev) DPPR was 82.9% (15.6). Being female (OR = 0.85, 95%CI: 0.84-0.86), age ≥85 years (OR = 0.77, 95%CI: 0.76-0.79), and multimorbidity (≥4 diseases, OR = 0.88, 95%CI: 0.86-0.90) were associated with lower medication adherence. A higher DPPR was associated with clinical outcomes-in particular, improved survival (HR = 0.93 for 10/100-point increase, 95%CI: 0.92-0.94) and lower incidence in nursing home admissions (SDHR = 0.95, 95%CI: 0.93-0.97). Adherence to the most common chronic drugs co-prescribed to the older population was high. Better multiple medication adherence was associated with better clinical outcomes.
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