Evidence map›Paper›PMID 35565085›Full record

ArticleInternational journal of environmental research and public health2022

Counteractive Effects of IL-33 and IL-37 on Inflammation in Osteoarthritis.

Vikrant Rai, Matthew F Dilisio, Farial Samadi, Devendra K Agrawal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Surgical interventions in Severe Osteoarthritis: Pros and Cons.Journal of orthopaedics and sports medicine · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Orthopedic Dermatopathies: Skin Manifestations in Orthopedic Conditions.Journal of orthopaedics and sports medicine · 2024
    Article
  17. Article
  18. The Role of Alarmins in Osteoarthritis Pathogenesis: HMGB1, S100B and IL-33.International journal of molecular sciences · 2023
    Review
  19. Review
  20. IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Vikrant RaiDepartment of Translational Research, Western University of Health Sciences, Pomona, CA 91766, USA.
Matthew F DilisioDepartment of Orthopedic Surgery, Creighton University School of Medicine, Omaha, NE 68178, USA.
Farial SamadiDepartment of Biology, College of Arts and Sciences, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Devendra K AgrawalDepartment of Translational Research, Western University of Health Sciences, Pomona, CA 91766, USA.ORCID 0000-0001-5445-0013
Western University of Health Sciences · USCreighton University · USUniversity of Nebraska at Omaha · US

Funding

VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASER01HL116042 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2012 to 2016
$3.3M
NHLBI NIH HHS R01 HL116042
6 · The paper itself

Abstract

Osteoarthritis (OA) is a chronic inflammatory disease where pro-inflammatory cytokines, damage-associated molecular patterns (DAMPs), and macrophages play a crucial role. However, the interactive role of these mediators, the exact cause precipitating OA and definitive treatment for OA are not known yet. Moreover, the interactive role of interleukin (IL)-33 and IL-37 with other factors in the pathogenesis of OA has not been discussed elaborately. In this study, we analyzed the expression of IL-33 and IL-37 in human OA knee and hip joint cartilage tissues. The effect of increased DAMPs, IL-33, and IL-37 on IL-6, tumor necrosis factor (TNF)-α, toll-like receptors (TLRs), and matrix metalloproteinases (MMPs) expression was delineated using human normal and osteoarthritic chondrocytes. The effect of anti-inflammatory cytokine IL-37 on various mediators of inflammation in the presence of IL-33, rHMGB-1, and LPS was investigated to delineate the effects of IL-37. Further, the effects of blocking IL-33 downstream signaling and the effects of IL-33 and IL-37 on macrophage polarization were assessed along with examining the macrophage phenotypes in human OA cartilage tissues. The results of this study revealed increased expression of IL-33 in OA cartilage and that IL-33 increases IL-6, TNF-α, TLRs, and MMPs expression and favors phenotypic conversion towards the M1 phenotype, while IL-37 and blocking IL-33 receptor ST2 have opposite effects. Overall, the results suggest that blocking IL-33 and increasing IL-37 act synergistically to attenuate inflammation and might serve as potential therapeutics in OA.

Indexed as

Cartilage, ArticularOsteoarthritisCytokinesHumansInflammationInterleukin-1Interleukin-33Interleukin-6Matrix MetalloproteinasesTumor Necrosis Factor-alphaCytokinesIL33 protein, humanIL37 protein, humanInterleukin-1Interleukin-33Interleukin-6Matrix MetalloproteinasesTumor Necrosis Factor-alphadamage-associated molecular patternsinflammationInterleukin-33Interleukin-37Macrophagesmatrix metalloproteinasesosteoarthritisToll-like receptors

Identifiers

PMID35565085
PMCPMC9100324
OpenAlexW4229334668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.