Evidence map›Paper›PMID 35564779›Full record

SynthesisInternational journal of environmental research and public health2022

SARS-CoV-2 Circulation in the School Setting: A Systematic Review and Meta-Analysis.

Saverio Caini, Chiara Martinoli, Carlo La Vecchia, Sara Raimondi, Federica Bellerba, Oriana D'Ecclesiis, Clementina Sasso, Alessandra Basso, Giulio Cammarata, Sara Gandini

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Saverio CainiInstitute for Cancer Research, Prevention, and Clinical Network (ISPRO), Via Cosimo il Vecchio 2, 50139 Florence, Italy.ORCID 0000-0002-2262-1102
Chiara MartinoliDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Giuseppe Ripamonti 435, 20141 Milan, Italy.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, Università Degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0003-1441-897X
Sara RaimondiDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Giuseppe Ripamonti 435, 20141 Milan, Italy.
Federica BellerbaDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Giuseppe Ripamonti 435, 20141 Milan, Italy.
Oriana D'EcclesiisDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Giuseppe Ripamonti 435, 20141 Milan, Italy.
Clementina SassoThe Italian National Institute for Astrophysics (INAF)-Osservatorio Astronomico di Capodimonte, Salita Moiariello 16, 80131 Naples, Italy.ORCID 0000-0002-5163-5837
Alessandra BassoCentre for Philosophy of Social Science (TINT), Unit of Practical Philosophy, Department of Political and Economic Studies, University of Helsinki, P.O. Box 24, 00014 Helsinki, Finland.ORCID 0000-0002-2202-6055
Giulio CammarataDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Giuseppe Ripamonti 435, 20141 Milan, Italy.
Sara GandiniDepartment of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Giuseppe Ripamonti 435, 20141 Milan, Italy.ORCID 0000-0002-1348-4548
Ripamonti · ITAstronomical Observatory of Capodimonte · ITUniversity of Helsinki · FIUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of children to viral spread in schools is still debated. We conducted a systematic review and meta-analysis of studies to investigate SARS-CoV-2 transmission in the school setting. Literature searches on 15 May 2021 yielded a total of 1088 publications, including screening, contact tracing, and seroprevalence studies. MOOSE guidelines were followed, and data were analyzed using random-effects models. From screening studies involving more than 120,000 subjects, we estimated 0.31% (95% confidence interval (CI) 0.05-0.81) SARS-CoV-2 point prevalence in schools. Contact tracing studies, involving a total of 112,622 contacts of children and adults, showed that onward viral transmission was limited (2.54%, 95% CI 0.76-5.31). Young index cases were found to be 74% significantly less likely than adults to favor viral spread (odds ratio (OR) 0.26, 95% CI 0.11-0.63) and less susceptible to infection (OR 0.60; 95% CI 0.25-1.47). Lastly, from seroprevalence studies, with a total of 17,879 subjects involved, we estimated that children were 43% significantly less likely than adults to test positive for antibodies (OR 0.57, 95% CI 0.49-0.68). These findings may not applied to the Omicron phase, we further planned a randomized controlled trial to verify these results.

Indexed as

COVID-19SARS-CoV-2Contact TracingHumansSchoolsSeroepidemiologic Studiescontract tracinginfectionsmeta-analysisSARS-CoV-2schoolsscreeningstudentssusceptibilityteachers

Identifiers

PMID35564779
PMCPMC9099553
OpenAlexW4225509882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.