ArticleInternational journal of environmental research and public health2022
Exploring Blue Spaces' Effects on Childhood Leukaemia Incidence: A Population-Based Case-Control Study in Spain.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Risk factors for mortality in children with moderate-to-severe ARDS with concurrent hematological or immune-related diseases: a retrospective analysis.BMC pediatrics · 2025Observational
- Exposure to residential traffic and trajectories of unhealthy ageing: results from a nationally-representative cohort of older adults.Environmental health : a global access science source · 2024Article
- Knowledge, attitude, and practice toward family-based treatment among parents of children with leukemia.Frontiers in public health · 2024Article
- Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study.Antioxidants (Basel, Switzerland) · 2023Article
- Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence.International journal of environmental research and public health · 2023Article
- Childhood acute lymphoblastic leukemia survival and spatial analysis of socio-environmental risks in Mexico.Frontiers in oncology · 2023Article
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8 authors.
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Abstract
backgroundBlue spaces have been a key part of human evolution, providing resources and helping economies develop. To date, no studies have been carried out to explore how they may be linked to paediatric oncological diseases.
objectivesTo explore the possible relationship of residential proximity to natural and urban blue spaces on childhood leukaemia.
methodsA population-based case-control study was conducted in four regions of Spain across the period 2000-2018. A total of 936 incident cases and 5616 controls were included, individually matched by sex, year of birth and place of residence. An exposure proxy with four distances (250 m, 500 m, 750 m, and 1 km) to blue spaces was built using the geographical coordinates of the participants' home residences. Odds ratios (ORs) and 95% confidence intervals (95%CIs) for blue-space exposure were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic and environmental covariates.
resultsA decrease in overall childhood leukaemia and ALL-subtype incidence was found as we came nearer to children's places of residence, showing, for the study as a whole, a reduced incidence at 250 m (odds ratio (OR) = 0.77; 95%CI = 0.60-0.97), 500 m (OR = 0.78; 95%CI = 0.65-0.93), 750 m (OR = 0.80; 95%CI = 0.69-0.93), and 1000 m (OR = 0.84; 95%CI = 0.72-0.97). AML model results showed an increasing incidence at closest to subjects' homes (OR at 250m = 1.06; 95%CI=0.63-1.71).
conclusionsOur results suggest a possible association between lower childhood leukaemia incidence and blue-space proximity. This study is a first approach to blue spaces' possible effects on childhood leukaemia incidence; consequently, it is necessary to continue studying these spaces-while taking into account more individualised data and other possible environmental risk factors.
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