Evidence map›Paper›PMID 35563871›Full record

ArticleCells2022

Tany-Seq: Integrated Analysis of the Mouse Tanycyte Transcriptome.

Andrew I Sullivan, Matthew J Potthoff, Kyle H Flippo

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew I SullivanDepartment of Neuroscience and Pharmacology, College of Medicine, University of Iowa Carver, Iowa City, IA 52242, USA.ORCID 0000-0003-4430-3540
Matthew J PotthoffDepartment of Neuroscience and Pharmacology, College of Medicine, University of Iowa Carver, Iowa City, IA 52242, USA.
Kyle H FlippoDepartment of Neuroscience and Pharmacology, College of Medicine, University of Iowa Carver, Iowa City, IA 52242, USA.ORCID 0000-0001-9667-7056
University of Iowa · US

Funding

Regulation of Metabolism by FGF21R01DK106104 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Matthew Joseph Potthoff · 2015 to 2026
$6.2M
Diabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8M
Central Mechanisms Regulating Macronutrient IntakeI01BX004634 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI Matthew Joseph Potthoff · 2019 to 2026
–
BLRD VA I01 BX004634NIDDK NIH HHS R01 DK106104NIDDK NIH HHS T32 DK112751
6 · The paper itself

Abstract

The ability to maintain energy homeostasis is necessary for survival. Recently, an emerging role for ependymogial cells, which line the third ventricle in the hypothalamus in the regulation of energy homeostasis, has been appreciated. These cells are called tanycytes and are physically at the interface of brain communication with peripheral organs and have been proposed to mediate the transport of circulating hormones from the third ventricle into the parenchyma of the hypothalamus. Despite the important role tanycytes have been proposed to play in mediating communication from the periphery to the brain, we understand very little about the ontology and function of these cells due to their limited abundance and lack of ability to genetically target this cell population reliably. To overcome these hurdles, we integrated existing hypothalamic single cell RNA sequencing data, focusing on tanycytes, to allow for more in-depth characterization of tanycytic cell types and their putative functions. Overall, we expect this dataset to serve as a resource for the research community.

Indexed as

Ependymoglial CellsTranscriptomeAnimalsHomeostasisHypothalamusMicehypothalamusneurogenesisontologyscRNAseqtanycyte

Identifiers

PMID35563871
PMCPMC9104898
OpenAlexW4228998547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.