Tracking the Activation of Heat Shock Signaling in Cellular Protection and Damage.

Shisui Torii, Pasko Rakic

Open access · goldAbstract read

In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 96% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

SIZ1-mediated SUMOylation of HAT1 enhances plant thermotolerance in Arabidopsis.The Plant journal : for cell and molecular biology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shisui ToriiDepartment of Neuroscience, School of Medicine, Yale University, New Haven, CT 06510, USA.

Pasko RakicDepartment of Neuroscience, School of Medicine, Yale University, New Haven, CT 06510, USA.

Yale University · US

Funding

Origin of Cortical Species-specific Distinctions.R01DA023999 · NIDA · YALE UNIVERSITY · PI RAKIC, PASKO · 2008 to 2019

$7.9M

Origin of Cortical Species-specific DistinctionsR37DA023999 · NIDA · YALE UNIVERSITY · PI PASKO RAKIC · 2020 to 2026

$5.6M

NIDA NIH HHS R01 DA023999NIDA NIH HHS R37 DA023999

6 · The paper itself

Abstract

Heat Shock (HS) signaling is activated in response to various types of cellular stress. This activation serves to protect cells from immediate threats in the surrounding environment. However, activation of HS signaling occurs in a heterogeneous manner within each cell population and can alter the epigenetic state of the cell, ultimately leading to long-term abnormalities in body function. Here, we summarize recent research findings obtained using molecular and genetic tools to track cells where HS signaling is activated. We then discuss the potential further applications of these tools, their limitations, and the necessary caveats in interpreting data obtained with these tools.

Indexed as

Heat-Shock ResponseSignal TransductionCytoprotectiondetection of injuryepigeneticsgenetic recombinationHeat Shock Factor 1Heat Shock Protein 70Heat Shock signalingheterogeneityreporter micetranscriptional amplificationtranscriptional bursting

Identifiers

PMID35563865

DOI10.3390/cells11091561

PMCPMC9104565

OpenAlexW4280543297

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.