Evidence map›Paper›PMID 35563734›Full record

ArticleCells2022

Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis.

Yotam David, Inês Gomes Castro, Eden Yifrach, Chen Bibi, Enas Katawi, Dekel Yahav Har-Shai, Sagie Brodsky, Naama Barkai, Tommer Ravid, Miriam Eisenstein and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yotam DavidDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0003-4992-7045
Inês Gomes CastroDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0003-4669-985X
Eden YifrachDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0001-5074-0048
Chen BibiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Enas KatawiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Dekel Yahav Har-ShaiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Sagie BrodskyDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Naama BarkaiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Tommer RavidDepartment of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0002-0453-016X
Miriam EisensteinDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Shmuel PietrokovskiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Maya SchuldinerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0001-9947-115X
Einat ZalckvarDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Weizmann Institute of Science · ILHebrew University of Jerusalem · IL

Funding

European Research Council 864068
6 · The paper itself

Abstract

Peroxisomes host essential metabolic enzymes and are crucial for human health and survival. Although peroxisomes were first described over 60 years ago, their entire proteome has not yet been identified. As a basis for understanding the variety of peroxisomal functions, we used a high-throughput screen to discover peroxisomal proteins in yeast. To visualize low abundance proteins, we utilized a collection of strains containing a peroxisomal marker in which each protein is expressed from the constitutive and strong

Indexed as

PeroxisomesSaccharomyces cerevisiae ProteinsHumansLysineProteomeSaccharomyces cerevisiaeLysineProteomeSaccharomyces cerevisiae Proteinshigh-content screenLys1lysineperoxisomePex5protein targetingSaccharomyces cerevisiaesaccharopine

Identifiers

PMID35563734
PMCPMC9104712
OpenAlexW4280549064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.