ReviewCells2022
Towards an Improved Understanding of the Effects of Elevated Progesterone Levels on Human Endometrial Receptivity and Oocyte/Embryo Quality during Assisted Reproductive Technologies.
Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Adverse pregnancy and perinatal outcomes in women with polycystic ovary syndrome undergoing assisted reproductive technology: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Artificial intelligence-driven precision treatment of reproductive medicine-related diseases: the optimal protocol choice for IVF-ET.Journal of advanced research · 2026Article
- Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility.JCI insight · 2026Article
- Administration of Human Chorionic Gonadotropin Combined with Phenylbutazone at the Time of Embryo Transfer Synergistically Improves Pregnancy Rates in Dromedary Camels.Veterinary sciences · 2026Article
- Association of estradiol and progesterone levels on human chorionic gonadotropin day with pregnancy outcomes in IVF/ICSI fresh embryo transfer.Frontiers in endocrinology · 2026Article
- Multidimensional regulatory architecture of endometrial receptivity and its translational implications for implantation failure.Frontiers in endocrinology · 2026Review
- Late follicular phase progesterone levels andFrontiers in endocrinology · 2026Article
- Impact of GnRH antagonist protocols versus progestin-primed ovarian stimulation on reproductive outcomes in advanced reproductive age women: a propensity score-matched retrospective cohort study.Frontiers in endocrinology · 2026Article
- Development of a New Personalized Molecular Test Based on Endometrial Receptivity and Maternal-Fetal Dialogue: Adhesio.Biochemical genetics · 2025Article
- Machine learning prediction of clinical pregnancy in endometriosis patients following fresh IVF/ICSI-ET.European journal of medical research · 2025Article
- The relationship between serum estradiol and progesterone levels one day before frozen embryo transfer and pregnancy rates in artificially prepared frozen embryo cycles: are there any threshold serum hormone levels to predict pregnancy in luteal support by the vaginal and subcutaneous route combined?Journal of the Turkish German Gynecological Association · 2025Article
- Potential of growth factors and steroid hormones from cell cultures to improveOpen veterinary journal · 2025Review
- Age does not affect maximal endometrial thickness achieved in frozen embryo transfer cycles: a SARTCORS study.Reproductive biology and endocrinology : RB&E · 2025Article
- Dynamic expression of endometrial adhesion G protein-coupled receptors during the menstrual cycle and early mouse pregnancy: modulation by ovarian stimulation.F&S science · 2025Article
- An analysis of freeze-all cycles to investigate the association between elevated progesterone on day of trigger and oocyte quality.Journal of assisted reproduction and genetics · 2025Article
- Analysis of influencing factors on the rate of high-quality embryos induced by rectangular plan during in vitro fertilization.Pakistan journal of medical sciences · 2025Article
- Association between iron deficiency and fertility.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- Risk of placenta previa in assisted reproductive technology: A Nordic population study with sibling analyses.PLoS medicine · 2025Article
- Impact of platelet-rich plasma intrauterine perfusion on endometrial receptivity and pregnancy outcomes in patients with recurrent implantation failure and thin endometrium.American journal of translational research · 2025Article
- Effect of progesterone levels on the hCG trigger day and the progesterone-to-basal progesterone ratio on pregnancy outcomes in fresh IVF/ICSI cycles with GnRH antagonist protocol: a retrospective cohort study.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovarian stimulation is an indispensable part of IVF and is employed to produce multiple ovarian follicles. In women who undergo ovarian stimulation with gonadotropins, supraphysiological levels of estradiol, as well as a premature rise in progesterone levels, can be seen on the day of hCG administration. These alterations in hormone levels are associated with reduced embryo implantation and pregnancy rates in IVF cycles with a fresh embryo transfer. This article aims to improve the reader's understanding of the effects of elevated progesterone levels on human endometrial receptivity and oocyte/embryo quality. Based on current clinical data, it appears that the premature rise in progesterone levels exerts minimal or no effects on oocyte/embryo quality, while advancing the histological development of the secretory endometrium and displacing the window of implantation. These clinical findings strongly suggest that reduced implantation and pregnancy rates are the result of a negatively affected endometrium rather than poor oocyte/embryo quality. Understanding the potential negative impact of elevated progesterone levels on the endometrium is crucial to improving implantation rates following a fresh embryo transfer. Clinical studies conducted over the past three decades, many of which have been reviewed here, have greatly advanced our knowledge in this important area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.