ArticleCells2022
Cytotoxicity and Wound Closure Evaluation in Skin Cell Lines after Treatment with Common Antiseptics for Clinical Use.
Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Expert consensus on the use of oral antiseptics in oral surgery: Evidence-based clinical practice guidelines.Medicina oral, patologia oral y cirugia bucal · 2026Guideline
- Cold Atmospheric Plasma Disrupts Microbial Wound Bioburden: In Vitro, Porcine MRSA Biofilm, and Clinical Fluorescence Evidence from Bench to Bedside.Biomedicines · 2026Article
- Past, Present, and Future of Sodium Hypochlorite in Dermatology: A Scoping Review.American journal of clinical dermatology · 2026Article
- Saline solution vs. stabilized isotonic sodium hypochlorite lavage in complicated appendicitis: a comparative study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Elevated Antibacterial Activity of a Polygalacturonic + Caprylic Acids Wound Ointment Compared with Hypochlorous Acid in a Three-Dimensional Wound Biofilm Model.Pathogens (Basel, Switzerland) · 2026Article
- Iodine-Based Wound Dressing Versus Antibiotic Therapy for Postoperative Symptom Relief in Third Molar Surgery.Cureus · 2026Article
- Repercussions of Symbiotic Bacteria Associated with Entomopathogenic Nematodes and Their Biogenic Silver Nanoparticles on Immune Responses at Root-Knot Nematode Suppression.Microorganisms · 2025Article
- Anti-inflammatory, cytotoxic, and potential wound healing effects of phytofabricated Ehretia rigida leaf aqueous extract-synthesized silver nanoparticles.Scientific reports · 2025Article
- Article
- Smart Thermoresponsive Sol-Gel Formulation of Polyhexanide for Rapid and Painless Burn and Wound Management.Polymers · 2025Article
- Chemical Composition, Quality, and Bioactivity ofAntioxidants (Basel, Switzerland) · 2025Article
- The Role of Lactic Acid in Episiotomy Wound Healing: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Development of Solid Nanosystem for Delivery of Chlorhexidine with Increased Antimicrobial Activity and Decreased Cytotoxicity: Characterization and In Vitro and In Ovo Toxicological Screening.Molecules (Basel, Switzerland) · 2025Article
- Sustainable Primary Cell Banking for Topical Compound Cytotoxicity Assays: Protocol Validation on Novel Biocides and Antifungals for Optimized Burn Wound Care.European burn journal · 2024Article
- Topical oxygen therapy as a novel strategy to promote wound healing and control the bacteria in implantology, oral surgery and periodontology: A review.The Saudi dental journal · 2024Review
- Antibiotics againstPharmaceutics · 2024Article
- Article
- Article
- Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review.Membranes · 2022Review
- Rapid-killing efficacy substantiates the antiseptic property of the synergistic combination of carvacrol and nerol against nosocomial pathogens.Archives of microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, new therapies, such as skin cell lines injections, have emerged to promote re-epithelialization of damaged areas such as chronic ulcers or to treat patients with severe burns. Antiseptics are commonly used during wound clinical management to avoid serious infections, but they may delay the healing process due to their apparent cytotoxicity to skin cells. The cytotoxicity of ethanol, chlorhexidine digluconate, sodium hypochlorite, povidone iodine and polyhexanide was evaluated in this in vitro study on human fibroblasts and keratinocytes. Treatments were applied to each cell type culture every 48 h for 14 days. To determine the cytotoxic of antiseptics, cell viability (Live/Dead
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.