Evidence map›Paper›PMID 35563610›Full record

ArticleInternational journal of molecular sciences2022

Loading of Polydimethylsiloxane with a Human ApoB-Derived Antimicrobial Peptide to Prevent Bacterial Infections.

Maria De Luca, Rosa Gaglione, Bartolomeo Della Ventura, Angela Cesaro, Rocco Di Girolamo, Raffaele Velotta, Angela Arciello

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Advanced delivery systems for peptide antibiotics.Advanced drug delivery reviews · 2023
    Review
  5. Frontiers in Antimicrobial Materials.International journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Maria De LucaDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0001-6037-8775
Rosa GaglioneDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0003-2391-0237
Bartolomeo Della VenturaDepartment of Physics "E. Pancini", University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0003-2920-6187
Angela CesaroDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0003-0435-5346
Rocco Di GirolamoDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0001-8815-2997
Raffaele VelottaDepartment of Physics "E. Pancini", University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0003-1077-8353
Angela ArcielloDepartment of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.ORCID 0000-0001-8269-6459
University of Naples Federico II · ITIstituto Nazionale Biostrutture e Biosistemi · ITTranslational Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundmedical device-induced infections affect millions of lives worldwide and innovative preventive strategies are urgently required. Antimicrobial peptides (AMPs) appear as ideal candidates to efficiently functionalize medical devices surfaces and prevent bacterial infections. In this scenario, here, we produced antimicrobial polydimethylsiloxane (PDMS) by loading this polymer with an antimicrobial peptide identified in human apolipoprotein B, r(P)ApoB

methodsonce obtained loaded PDMS, its structure, anti-infective properties, ability to release the peptide, stability, and biocompatibility were evaluated by FTIR spectroscopy, water contact angle measurements, broth microdilution method, time-killing kinetic assays, quartz crystal microbalance analyses, MTT assays, and scanning electron microscopy analyses.

resultsPDMS was loaded with r(P)ApoB

conclusionsan easy procedure to functionalize PDMS with r(P)ApoB

Indexed as

Anti-Infective AgentsBacterial InfectionsAnti-Bacterial AgentsAntimicrobial PeptidesApolipoproteins BBiofilmsDimethylpolysiloxanesHumansPeptidesPolymersAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial PeptidesApolipoproteins BDimethylpolysiloxanesPeptidesPolymersantimicrobial peptidesantimicrobial resistanceantimicrobial surfacesbacterial infectionsbiofilmshost defense peptidesinfection preventionpolydimethylsiloxane

Identifiers

PMID35563610
PMCPMC9103716
OpenAlexW4229332864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.