Evidence map›Paper›PMID 35563530›Full record

ReviewInternational journal of molecular sciences2022

Novel Models of Crohn's Disease Pathogenesis Associated with the Occurrence of Mitochondrial Dysfunction in Intestinal Cells.

Alexander Blagov, Elena B Zhigmitova, Margarita A Sazonova, Liudmila M Mikhaleva, Vladislav Kalmykov, Nikolay K Shakhpazyan, Varvara A Orekhova, Alexander N Orekhov

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alexander BlagovLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Elena B ZhigmitovaFederal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery, A.P. Avtsyn Research Institute of Human Morphology", 117418 Moscow, Russia.
Margarita A SazonovaLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Liudmila M MikhalevaFederal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery, A.P. Avtsyn Research Institute of Human Morphology", 117418 Moscow, Russia.ORCID 0000-0003-2052-914X
Vladislav KalmykovLaboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Nikolay K ShakhpazyanFederal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery, A.P. Avtsyn Research Institute of Human Morphology", 117418 Moscow, Russia.ORCID 0000-0003-3386-7746
Varvara A OrekhovaSkolkovo Innovative Center, Institute for Atherosclerosis Research, 121609 Moscow, Russia.
Alexander N OrekhovSkolkovo Innovative Center, Institute for Atherosclerosis Research, 121609 Moscow, Russia.ORCID 0000-0002-3318-4681
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUResearch Institute of Human Morphology · RUInstitute for Atherosclerosis Research · RU

Funding

Russian Science Foundation 22-25-00480
6 · The paper itself

Abstract

Crohn's disease remains one of the challenging problems of modern medicine, and the development of new and effective and safer treatments against it is a dynamic field of research. To make such developments possible, it is important to understand the pathologic processes underlying the onset and progression of Crohn's disease at the molecular and cellular levels. During the recent years, the involvement of mitochondrial dysfunction and associated chronic inflammation in these processes became evident. In this review, we discuss the published works on pathogenetic models of Crohn's disease. These models make studying the role of mitochondrial dysfunction in the disease pathogenesis possible and advances the development of novel therapies.

Indexed as

Crohn DiseaseHumansIntestinesMitochondriaCrohn’s diseaseinflammationmitochondrion

Identifiers

PMID35563530
PMCPMC9102004
OpenAlexW4229037725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.