Evidence map›Paper›PMID 35563527›Full record

ArticleInternational journal of molecular sciences2022

DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin.

Yi Feng, Shaon Borosha, Anamika Ratri, Eun Bee Lee, Huizhen Wang, Timothy A Fields, William H Kinsey, Jay L Vivian, M A Karim Rumi, Patrick E Fields

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yi FengDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Shaon BoroshaDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Anamika RatriDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Eun Bee LeeDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Huizhen WangDepartment of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0002-3184-4690
Timothy A FieldsDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
William H KinseyDepartment of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jay L VivianDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
M A Karim RumiDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Patrick E FieldsDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
University of Kansas Medical Center · US

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ABRAHAMSON, DALE R · 2017 to 2021
$5.6M
The Role of the Histone Methyltransferase DOT1L in ErythropoiesisR01DK091277 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI FIELDS, PATRICK E · 2012 to 2016
$1.6M
NCI NIH HHS P30 CA168524NIDDK NIH HHS R01 DK091277NIGMS NIH HHS P30 GM122731NIH HHS R01DK091277
6 · The paper itself

Abstract

Erythropoietin (EPO) signaling plays a vital role in erythropoiesis by regulating proliferation and lineage-specific differentiation of murine hematopoietic progenitor cells (HPCs). An important downstream response of EPO signaling is calcium (Ca

Indexed as

CalciumErythropoietinHistone-Lysine N-MethyltransferaseAnimalsCalcium, DietaryEpoetin AlfaErythroid Precursor CellsErythropoiesisMiceReceptors, ErythropoietinTRPC6 Cation ChannelTRPC Cation ChannelsCalciumCalcium, DietaryDot1l protein, mouseEpoetin AlfaErythropoietinHistone-Lysine N-MethyltransferaseReceptors, ErythropoietinTRPC6 Cation ChannelTRPC Cation Channelscalcium influxDOT1Lerythroid progenitorserythropoietinTRPC6

Identifiers

PMID35563527
PMCPMC9099724
OpenAlexW4229010339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.