ArticleInternational journal of molecular sciences2022
Chitosan-Enriched Solution Blow Spun Poly(Ethylene Oxide) Nanofibers with Poly(Dimethylsiloxane) Hydrophobic Outer Layer for Skin Healing and Regeneration.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Airbrush-based solution blow spinning of cellulose acetate/poly(vinyl acetate) blends for nonwoven mat formation.RSC advances · 2026Article
- Nontoxic, Eco-Friendly, Low-Cost Spinning of Submicrometric Fibers from Water-Soluble Polymers Using Protic Ionic Liquids.ACS omega · 2026Article
- Biomaterials in pancreatic surgery: progress and challenges in preoperative, intraoperative and postoperative care.Theranostics · 2026Review
- Protein and Polysaccharide Fibers via Air Jet Spinning: Emerging Techniques for Biomedical and Sustainable Applications.International journal of molecular sciences · 2024Review
- Biocompatible Native Hyaluronan Nanofibers Fabricated via Aqueous PEO-Assisted Electrospinning and Heat-Quench Process.ACS omega · 2024Article
- Article
- Chitosan/Pomegranate Seed Oil Emulgel Composition as a New Strategy for Dermal Delivery of Hydrocortisone.International journal of molecular sciences · 2024Article
- Influence of Fast Drying on the Morphology of α-FeNanomaterials (Basel, Switzerland) · 2024Article
- A review of the current state of natural biomaterials in wound healing applications.Frontiers in bioengineering and biotechnology · 2024Review
- The Investigation of the Production of Salt-Added Polyethylene Oxide/Chitosan Nanofibers.Materials (Basel, Switzerland) · 2023Article
- Fibrous Structures Produced Using the Solution Blow-Spinning Technique for Advanced Air Filtration Process.Materials (Basel, Switzerland) · 2023Article
- Advances in Biomedical Applications of Solution Blow Spinning.International journal of molecular sciences · 2023Review
- Natural and Synthetic Polymeric Biomaterials for Application in Wound Management.Journal of functional biomaterials · 2023Review
- Recent advances in the medical applications of hemostatic materials.Theranostics · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Chitosan (CS)/poly(ethylene oxide) (PEO)-based nanofiber mats have attracted particular attention as advanced materials for medical and pharmaceutical applications. In the scope of present studies, solution blow spinning was applied to produce nanofibers from PEO and CS and physicochemical and biopharmaceutical studies were carried out to investigate their potential as wound nanomaterial for skin healing and regeneration. Additional coating with hydrophobic poly(dimethylsiloxane) was applied to favor removal of nanofibers from the wound surface. Unmodified nanofibers displayed highly porous structure with the presence of uniform, randomly aligned nanofibers, in contrast to coated materials in which almost all the free spaces were filled in with poly(dimethylsiloxane). Infrared spectroscopy indicated that solution blow technique did not influence the molecular nature of native polymers. Obtained nanofibers exhibited sufficient wound exudate absorbency, which appears beneficial to moisturize the wound bed during the healing process. Formulations displayed greater tensile strength as compared to commercial hydrofiber-like dressing materials comprised of carboxymethylcellulose sodium or calcium alginate, which points toward their protective function against mechanical stress. Coating with hydrophobic poly(dimethylsiloxane) (applied to favor nanofiber removal from the wound surface) impacted porosity and decreased both mechanical properties and adherence to excised human skin, though the obtained values were comparable to those attained for commercial hydrofiber-like materials. In vitro cytotoxicity and irritancy studies showed biocompatibility and no skin irritant response of nanofibers in contact with a reconstituted three-dimensional human skin model, while scratch assay using human fibroblast cell line HDFa revealed the valuable potential of CS/PEO nanofibers to promote cell migration at an early stage of injury.
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Registered trials
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