Evidence map›Paper›PMID 35563488›Full record

ArticleInternational journal of molecular sciences2022

Combined Transcriptomic and Protein Array Cytokine Profiling of Human Stem Cells from Dental Apical Papilla Modulated by Oral Bacteria.

Valeriia Zymovets, Yelyzaveta Razghonova, Olena Rakhimova, Karthik Aripaka, Lokeshwaran Manoharan, Peyman Kelk, Maréne Landström, Nelly Romani Vestman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Valeriia ZymovetsDepartment of Odontology, Umeå University, 901 85 Umea, Sweden.
Yelyzaveta RazghonovaDepartment of Microbiology, Virology and Biotechnology, Mechnikov National University, 65058 Odesa, Ukraine.
Olena RakhimovaDepartment of Odontology, Umeå University, 901 85 Umea, Sweden.ORCID 0000-0002-3536-4467
Karthik AripakaDepartment of Medical Biosciences, Umeå University, 901 85 Umea, Sweden.ORCID 0000-0001-5071-6187
Lokeshwaran ManoharanNational Bioinformatics Infrastructure Sweden, Lund University, 223 62 Lund, Sweden.ORCID 0000-0001-9751-5745
Peyman KelkSection for Anatomy, Department of Integrative Medical Biology (IMB), Umea University, 901 87 Umea, Sweden.
Maréne LandströmDepartment of Medical Biosciences, Umeå University, 901 85 Umea, Sweden.ORCID 0000-0001-6737-7230
Nelly Romani VestmanDepartment of Endodontics, Region of Västerbotten, 901 85 Umea, Sweden.ORCID 0000-0002-5674-8179
Umeå University · SELund University · SEVästerbotten County · SE

Funding

County Council of Vasterbotten 7003459 and 7003589Kempestiftelserna Kempe SMK.1966Knut and Alice Wallenberg Foundation 7003503the Region of Vasterbotten (Sweden) via ALF 7004361
6 · The paper itself

Abstract

Stem cells from the apical papilla (SCAP) are a promising resource for use in regenerative endodontic treatment (RET) that may be adversely affected by oral bacteria, which in turn can exert an effect on the success of RET. Our work aims to study the cytokine profile of SCAP upon exposure to oral bacteria and their supernatants-

Indexed as

Dental PapillaMouthOsteogenesisStem CellsAdultBacteriabeta CateninCell DifferentiationCytokinesHumansNF-kappa BProtein Array AnalysisRNA, MessengerTranscriptomeWnt Signaling Pathwaybeta CateninCytokinesNF-kappa BRNA, Messengercytokine secretionendodonticsFusobacterium nucleatumIL-6IL-8immune responseosteogenic potentialregenerative endodontic treatment (RET)stem cells from the apical papilla (SCAP)transcriptome analysis

Identifiers

PMID35563488
PMCPMC9103834
OpenAlexW4225422701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.