Evidence map›Paper›PMID 35563477›Full record

ArticleInternational journal of molecular sciences2022

Atherogenic Plasma Index or Non-High-Density Lipoproteins as Markers Best Reflecting Age-Related High Concentrations of Small Dense Low-Density Lipoproteins.

Sylwia Płaczkowska, Katarzyna Sołkiewicz, Iwona Bednarz-Misa, Ewa Maria Kratz

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sylwia PłaczkowskaDepartment of Laboratory Diagnostics, Teaching and Research Diagnostic Laboratory, Wroclaw Medical University, Borowska 211a St., 50-556 Wroclaw, Poland.ORCID 0000-0002-1466-3820
Katarzyna SołkiewiczDepartment of Laboratory Diagnostics, Division of Laboratory Diagnostics, Wroclaw Medical University, Borowska 211a St., 50-556 Wroclaw, Poland.ORCID 0000-0002-9449-2039
Iwona Bednarz-MisaDepartment of Biochemistry and Immunochemistry, Division of Medical Biochemistry, Wroclaw Medical University, M. Skłodowskiej-Curie 48/50 St., 50-369 Wroclaw, Poland.ORCID 0000-0001-7244-2017
Ewa Maria KratzDepartment of Laboratory Diagnostics, Division of Laboratory Diagnostics, Wroclaw Medical University, Borowska 211a St., 50-556 Wroclaw, Poland.ORCID 0000-0003-2948-4574

Funding

Polish Ministry of Health SUB.D270.21.096Polish Ministry of Health SUB.D272.20.008
6 · The paper itself

Abstract

The study aimed to assess the strength of the relationships between small dense low-density lipoproteins (sdLDL) and other parameters describing metabolic disorders and determine which of the lipid profile parameters can be used as markers of increased sdLDL concentration. The proposed model of sdLDL (examined by heparin−magnesium precipitation method) as a function of lipid parameters and atherogenic plasma indexes non-high-dense lipoproteins (non-HDL) and total cholesterol to high-dense lipoprotein ratio (TC/HDL), Atherogenic plasma index (API) is based on data from 485 participants divided into two age groups, <35≥ years. In multiple linear regression, sdLDL concentration was associated with the concentration of non-HDL-C (p = 0.043) and API value (p < 0.001) in participants <35 years, and with non-HDL-C (p < 0.001) and triglycerides (p = 0.020) concentration ≥35 years. The presence of abnormal values of API in participants <35 years and non-HDL-C in participants ≥35 years is a significant factor increasing the chances of the highest sdLDL (≥1.03 mmol/L) corresponding to Q4 in people without metabolic disorders. Different lipid parameters and atherogenicity indexes are associated with a high concentration of sdLDL depending on the age group. Abnormal API <35 years and non-HDL ≥35 years are associated with the highest sdLDL values and may be an indication for further specialist diagnosis of cardiovascular disease risk factors.

Indexed as

AtherosclerosisLipoproteins, LDLAdultBiomarkersHumansRisk FactorsTriglyceridesBiomarkersLipoproteins, LDLTriglyceridesatherogenic indexescardiovascular disease (CVD)high-density lipoproteins (HDL)low-density lipoproteins (LDL)small dense low-density lipoproteins (sdLDL)young adults

Identifiers

PMID35563477
PMCPMC9102874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.