ArticleInternational journal of molecular sciences2022
Integrative Analysis of Metabolomics and Transcriptomics Reveals Molecular Mechanisms of Anthocyanin Metabolism in the Zikui Tea Plant (
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 52 citations in OpenAlex.
- A long noncoding RNA modulates anthocyanin biosynthesis in Camellia sinensis.Communications biology · 2026Article
- Comprehensive transcriptomics and metabolomics reveal the coloring mechanism of purple Camellia tachangensis.BMC plant biology · 2025Article
- Integrated transcriptomics and metabolomics analysis of volatiles and variations in carotenoid biosynthesis during different developmental stages of Camellia huana.BMC plant biology · 2025Article
- CsHY5 Regulates Light-Induced Anthocyanin Accumulation inInternational journal of molecular sciences · 2025Article
- Metabolome and transcriptome analysis of anthocyanin biosynthesis reveal key metabolites and candidate genes in red-stemmed alfalfa (Medicago sativa).BMC genomics · 2025Article
- Integrated metabolomic and transcriptomic strategies to reveal adaptive mechanisms in barley plant during germination stage under waterlogging stress.Journal of plant research · 2025Article
- Revealing the Molecular Regulatory Mechanism of Flavonoid Accumulation in Tender Leaves of Tea Plants by Transcriptomic and Metabolomic Analyses.Plants (Basel, Switzerland) · 2025Article
- Deciphering the anthocyanin metabolism gene network in tea plant (Camellia sinensis) through structural equation modeling.BMC genomics · 2024Article
- Establishment of an efficient regeneration system of 'ZiKui' tea with hypocotyl as explants.Scientific reports · 2024Article
- Investigation of heat stress responses and adaptation mechanisms by integrative metabolome and transcriptome analysis in tea plants (Camellia sinensis).Scientific reports · 2024Article
- Multi-Omics Research Accelerates the Clarification of the Formation Mechanism and the Influence of Leaf Color Variation in Tea (Plants (Basel, Switzerland) · 2024Review
- Article
- Integrated Secondary Metabolomic and Antioxidant Ability Analysis Reveals the Accumulation Patterns of Metabolites inInternational journal of molecular sciences · 2023Article
- Comparative Transcriptome Analysis of Purple and Green Flowering Chinese Cabbage and Functional Analyses ofInternational journal of molecular sciences · 2023Article
- Research Progress on Anthocyanin-Mediated Regulation of 'Black' Phenotypes of Plant Organs.Current issues in molecular biology · 2023Review
- Application of Multi-Perspectives in Tea Breeding and the Main Directions.International journal of molecular sciences · 2023Review
- Harnessing Knowledge from Plant Functional Genomics and Multi-Omics for Genetic Improvement.International journal of molecular sciences · 2023Article
- High Light Intensity Triggered Abscisic Acid Biosynthesis Mediates Anthocyanin Accumulation in Young Leaves of Tea Plant (Antioxidants (Basel, Switzerland) · 2023Article
- Transcriptome and metabolome analysis reveals the effect of flavonoids on flower color variation inFrontiers in plant science · 2023Article
- Article
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9 authors at 1 institution in 1 country.
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Abstract
In this study, we performed an association analysis of metabolomics and transcriptomics to reveal the anthocyanin biosynthesis mechanism in a new purple-leaf tea cultivar Zikui (Camellia sinensis cv. Zikui) (ZK). Three glycosylated anthocyanins were identified, including petunidin 3-O-glucoside, cyanidin 3-O-galactoside, and cyanidin 3-O-glucoside, and their contents were the highest in ZK leaves at 15 days. This is the first report on petunidin 3-O-glucoside in purple-leaf tea. Integrated analysis of the transcriptome and metabolome identified eleven dependent transcription factors, among which CsMYB90 had strong correlations with petunidin 3-O-glucoside, cyanidin 3-O-galactoside, and cyanidin 3-O-glucoside (PCC > 0.8). Furthermore, we also identified key correlated structural genes, including two positively correlated F3’H (flavonoid-3′-hydroxylase) genes, two positively correlated ANS (anthocyanin synthase) genes, and three negatively correlated PPO (polyphenol oxidase) genes. Overexpression of CsMYB90 in tobacco resulted in dark-purple transgenic calluses. These results showed that the increased accumulation of three anthocyanins in ZK may promote purple-leaf coloration because of changes in the expression levels of genes, including CsMYB90, F3’Hs, ANSs, and PPOs. These findings reveal new insight into the molecular mechanism of anthocyanin biosynthesis in purple-leaf tea plants and provide a series of candidate genes for the breeding of anthocyanin-rich cultivars.
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