Evidence map›Paper›PMID 35563094›Full record

ArticleInternational journal of molecular sciences2022

Structure-Guided Engineering of a Family IV Cold-Adapted Esterase Expands Its Substrate Range.

Nehad Noby, Rachel L Johnson, Jonathan D Tyzack, Amira M Embaby, Hesham Saeed, Ahmed Hussein, Sherine N Khattab, Pierre J Rizkallah, D Dafydd Jones

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nehad NobyDepartment of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt.ORCID 0000-0002-3420-6168
Rachel L JohnsonMolecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.
Jonathan D TyzackEuropean Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Amira M EmbabyDepartment of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt.ORCID 0000-0001-8068-4200
Hesham SaeedDepartment of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt.ORCID 0000-0001-6600-1338
Ahmed HusseinDepartment of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria 21526, Egypt.
Sherine N KhattabDepartment of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.ORCID 0000-0002-3162-6386
Pierre J RizkallahSchool of Medicine, Cardiff University, Cardiff CF14 4XN, UK.ORCID 0000-0002-9290-0369
D Dafydd JonesMolecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.ORCID 0000-0001-7709-3995

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold active esterases have gained great interest in several industries. The recently determined structure of a family IV cold active esterase (EstN7) from

Indexed as

EsterasesEnzyme StabilityKineticsSubstrate SpecificityEsterasesenzyme structureprotein engineeringprotein stabilityserine esterasesubstrate specificity

Identifiers

PMID35563094
PMCPMC9100969

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.