Evidence map›Paper›PMID 35563059›Full record

ArticleInternational journal of molecular sciences2022

Spiro-Oxindole Skeleton Compounds Are Efficient Inhibitors for Indoleamine 2,3-Dioxygenase 1: An Attractive Target for Tumor Immunotherapy.

Daojing Yan, Jiakun Xu, Xiang Wang, Jiaxing Zhang, Gang Zhao, Yingwu Lin, Xiangshi Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Daojing YanDepartment of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200433, China.
Jiakun XuKey Laboratory of Sustainable Development of Polar Fisheries, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Laboratory for Marine Drugs and Byproducts of Pilot National Laboratory for Marine Science and Technology, Qingdao 266071, China.ORCID 0000-0002-8069-9717
Xiang WangDepartment of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200433, China.
Jiaxing ZhangKey Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Gang ZhaoKey Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Yingwu LinSchool of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China.
Xiangshi TanDepartment of Chemistry, Fudan University, 2005 Songhu Road, Shanghai 200433, China.
Fudan University · CNChinese Academy of Sciences · CNMinistry of Agriculture and Rural Affairs · CNUniversity of South China · CN

Funding

National Natural Science Foundation of China 21472027, 31670817, 21977017
6 · The paper itself

Abstract

Indoleamine 2,3-dioxygenase 1 (IDO1) is an attractive heme enzyme for its significant function in cancer immunotherapy. Potent IDO1 inhibitors have been discovered for decades, whereas no clinical drugs are used for cancer treatment up to now. With the goal of developing medically valuable IDO inhibitors, we performed a systematic study of SAR405838 analogs with a spiro-oxindole skeleton in this study. Based on the expression and purification of human IDO1, the inhibitory activity of spiro-oxindole skeleton compounds to IDO1 was evaluated by IC

Indexed as

Enzyme InhibitorsIndoleamine-Pyrrole 2,3,-DioxygenaseOxindolesSpiro CompoundsHumansImmunotherapyIndolesMolecular Docking SimulationStructure-Activity RelationshipEnzyme InhibitorsIndoleamine-Pyrrole 2,3,-DioxygenaseIndolesOxindolesSAR405838Spiro Compoundshemeproteinindoleamine 2,3-dioxygenase 1inhibitormetalloenzymemolecular docking

Identifiers

PMID35563059
PMCPMC9104902
OpenAlexW4224219409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.