ArticleInternational journal of molecular sciences2022
The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome.
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Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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0cells of the map it votes in
22citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome.Cellular and molecular gastroenterology and hepatology · 2026Article
- Glioblastoma pathophysiology: roles of aging driven changes in STAT3 interactions with NF-κB dimer components in the modulation of the mitochondrial melatonergic pathway and night-time inflammation resolution.Exploration of targeted anti-tumor therapy · 2026Review
- Macrophage-driven inflammation in inflammatory bowel disease: mechanisms and therapeutic opportunities.Frontiers in bioengineering and biotechnology · 2026Review
- P2 purinergic receptors regulate the progression of colorectal cancer.Purinergic signalling · 2025Review
- Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics.Journal of advanced research · 2025Review
- Interplay Between Dietary Phytochemicals and Gut Microbiota in Colorectal Cancer: Future Directions and Considerations.Journal of nutrition and metabolism · 2025Review
- Trp53 Deletion Promotes Exacerbated Colitis, Facilitates Lgr5+ Cancer Stem Cell Expansion, and Fuels Tumorigenesis in AOM/DSS-Induced Colorectal Cancer.International journal of molecular sciences · 2024Article
- Persistent Activation of the P2X7 Receptor Underlies Chronic Inflammation and Carcinogenic Changes in the Intestine.International journal of molecular sciences · 2024Review
- Changes in the Expression of Genes Regulating the Response to Hypoxia, Inflammation, Cell Cycle, Apoptosis, and Epithelial Barrier Functioning during Colitis-Associated Colorectal Cancer Depend on Individual Hypoxia Tolerance.International journal of molecular sciences · 2024Article
- Morphological Characteristics of Colon Tumors in Mice with Different Tolerance to Hypoxia.Bulletin of experimental biology and medicine · 2024Article
- Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice.Journal of nanobiotechnology · 2024Article
- Gut-immunity-joint axis: a new therapeutic target for gouty arthritis.Frontiers in pharmacology · 2024Review
- Identification of Hub genes with prognostic values in colorectal cancer by integrated bioinformatics analysis.Cancer biomarkers : section A of Disease markers · 2024Article
- The P2X7 Receptor in Autoimmunity.International journal of molecular sciences · 2023Review
- Exploration of the link between gut microbiota and purinergic signalling.Purinergic signalling · 2023Review
- P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity ofBiomedicines · 2023Article
- Inflammasome signaling in colorectal cancer.Translational research : the journal of laboratory and clinical medicine · 2023Review
- Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Claudio BernardazziDepartment of Pediatrics, University of Arizona, Tucson, AZ 85724, USA.
Morgana Teixeira Lima Castelo-BrancoDepartment of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Beatriz PêgoDepartment of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Beatriz Elias RibeiroDepartment of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Siane Lopes Bittencourt RosasDepartment of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Patrícia Teixeira SantanaDepartment of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.ORCID 0000-0001-7888-5249
João Carlos MachadoBiomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil.ORCID 0000-0003-2747-1702
Camille LealInstitute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.ORCID 0000-0002-1175-6896
Fabiano ThompsonInstitute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Robson Coutinho-SilvaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-7318-0204
Heitor Siffert Pereira de SouzaDepartment of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.ORCID 0000-0002-3647-7324
Universidade Federal do Rio de Janeiro · BR
Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.001279/2015Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.774/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E26/202.781/2017Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E26/210.886/2014National Council for Scientific and Technological Development 306634/2019-8
Abstract
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Indexed as
Colonic NeoplasmsColorectal NeoplasmsGastrointestinal MicrobiomeInflammasomesReceptors, Purinergic P2X7AnimalsCarcinogenesisCell Transformation, NeoplasticCytokinesDextran SulfateDisease Models, AnimalInflammationIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinCytokinesDextran SulfateInflammasomesIntracellular Signaling Peptides and ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP12 protein, mouseNlrp3 protein, mouseReceptors, Purinergic P2X7RNA, Ribosomal, 16Scolitis-associated colorectal cancergut microbiotainflammatory bowel diseaseP2X7Rpurinergic signaling
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.