Evidence map›Paper›PMID 35562955›Full record

ArticleInternational journal of molecular sciences2022

Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats.

Yulia N Grigorova, Ondrej Juhasz, Jeffrey M Long, Valentina I Zernetkina, Mikayla L Hall, Wen Wei, Christopher H Morrell, Natalia Petrashevskaya, Audrey Morrow, Katherine H LaNasa and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Long Term High-Salt Diet Induces Cognitive Impairments via Down-Regulating SHANK1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
  5. Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024
    Review
  6. CaCells · 2023
    Article
  7. Review
  8. Silencing ofJournal of the American Heart Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yulia N GrigorovaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Ondrej JuhaszLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Jeffrey M LongLaboratory of Behavioral Neuroscience, Neurocognitive Aging Section, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Valentina I ZernetkinaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Mikayla L HallLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Wen WeiLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Christopher H MorrellLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Natalia PetrashevskayaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Audrey MorrowLaboratory of Behavioral Neuroscience, Neurocognitive Aging Section, National Institute on Aging, NIH, Baltimore, MD 21224, USA.ORCID 0000-0001-9143-0708
Katherine H LaNasaLaboratory of Behavioral Neuroscience, Neurocognitive Aging Section, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Alexei Y BagrovLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Peter R RappLaboratory of Behavioral Neuroscience, Neurocognitive Aging Section, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Olga V FedorovaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
National Institute on Aging · US

Funding

Neurocognitive Aging: Experience-Dependent Dynamics, Plasticity and Network ContributionsZIAAG000350 · NIA · NATIONAL INSTITUTE ON AGING · PI RAPP, PETER R · 2009 to 2025
$30.9M
Exploring the involvement of Na pump inhibitor marinobufagenin in the interactions between age-associated vascular and neurodegenerative processes in cognitive impairment and Alzheimer's diseaseZIAAG000846 · NIA · NATIONAL INSTITUTE ON AGING · PI FEDOROVA, OLGA V · 2016 to 2025
$17.7M
Sodium pump ligands in blood pressure regulation and profibrotic signaling in hypertension, chronic kidney disease and aging in males and femalesZIAAG000609 · NIA · NATIONAL INSTITUTE ON AGING · PI FEDOROVA, OLGA V · 2009 to 2025
$17.3M
Marinobufagenin as a therapeutic targetZIAAG000869 · NIA · NATIONAL INSTITUTE ON AGING · PI LAKATTA, EDWARD · 2009 to 2025
$14.8M
6 · The paper itself

Abstract

The hypertensive response in Dahl salt-sensitive (DSS) rats on a high-salt (HS) diet is accompanied by central arterial stiffening (CAS), a risk factor for dementia, and heightened levels of a prohypertensive and profibrotic factor, the endogenous Na/K-ATPase inhibitor marinobufagenin (MBG). We studied the effect of the in vivo administration of MBG or HS diet on blood pressure (BP), CAS, and behavioral function in young DSS rats and normotensive Sprague-Dawley rats (SD), the genetic background for DSS rats. Eight-week-old male SD and DSS rats were given an HS diet (8% NaCl,

Indexed as

Cardiac GlycosidesCognitive DysfunctionHypertensionAnimalsBlood PressureBufanolidesMalePulse Wave AnalysisRatsRats, Inbred DahlRats, Sprague-DawleySodium ChlorideSodium Chloride, DietaryVascular RemodelingBufanolidesCardiac GlycosidesmarinobufageninSodium ChlorideSodium Chloride, Dietaryaortic pulse wave velocityarterial stiffnessbehavioral testscardiovascular remodelingDahl salt-sensitive ratsechocardiographyfibrosisgeneshypertensionmarinobufageninspatial memorysteroidal inhibitor of Na/K-ATPasevascular dementia

Identifiers

PMID35562955
PMCPMC9101263
OpenAlexW4224279185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.