ReviewInternational journal of molecular sciences2022
The Pathogenesis of Giant Condyloma Acuminatum (Buschke-Lowenstein Tumor): An Overview.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- MRI assessment of locoregional extent in a Buschke-Löwenstein tumor with histopathologically confirmed malignant transformation: A case report.Radiology case reports · 2026Article
- MIR31HG Modulates IL-4 Secretion by Keratinocytes and M2-Like Macrophage Polarization to Promote Local Immunosuppression in Condyloma Acuminata.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
- Surgical excision for giant condyloma acuminatum (Buschke-Löwenstein tumor): A case report.Case reports in women's health · 2026Article
- Giant condyloma acuminatum in a patient with HIV infection: a case report.AIDS research and therapy · 2026Article
- A Two-Decade Journey of Buschke-Löwenstein Tumor Without Malignant Transformation: Clinical Insights and Management.Cureus · 2026Article
- Buschke-Löwenstein Tumor of the Vulva: Clinical Neglect, Molecular Continuum, and Pathogenetic Insights.Cureus · 2026Article
- Visual clues - dermatological manifestations of sexually transmitted infections in men.Nature reviews. Urology · 2026Review
- Case Report: Definitive radiotherapy for inoperable anal Buschke-Löwenstein tumors: two cases with literature review.Frontiers in oncology · 2026Article
- Rapidly Progressive Perianal Giant Condyloma in an Immunocompetent Adolescent: An Unusual Abuse-Associated Case.Clinical, cosmetic and investigational dermatology · 2026Article
- Unmasking the Giant Condyloma: A Case Report and Literature Review of Buschke-Löwenstein Tumor.Cureus · 2025Article
- Buschke-Löwenstein Tumor: An Unusual Therapeutic Approach.GE Portuguese journal of gastroenterology · 2025Article
- Squamous Cell Carcinoma of the Vulva in Geriatric With Clinical Features of Papillomatous Plaque Resembling Anogenital Warts Caused by Human Papillomavirus Types 6 and 11.Case reports in dermatological medicine · 2025Article
- Article
- Development of human papillomavirus and its detection methods (Review).Experimental and therapeutic medicine · 2024Review
- Clinicopathological Findings and Comprehensive Review of Buschke-Lowenstein Tumors Based on a Case Study.Journal of personalized medicine · 2024Article
- Surgical treatment of perineal giant condylomata acuminata (Buschke Lowenstein tumor): Case series from a developing country.International journal of surgery case reports · 2024Article
- A rare presentation of a rare entity: giant condyloma (Buschke-Löwenstein) tumor.Journal of surgical case reports · 2024Article
- Radiation Therapy in the Management of Extensive Giant Condyloma Acuminata With Rectal Involvement: A Case Report.Cureus · 2024Article
- Case report: A case of giant breast skin warts caused by HPV infection.Frontiers in oncology · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare disease of the anogenital region. BLT is considered a locally aggressive tumor of benign histological appearance, but with the potential for destructive growth and high recurrence rates. BLT development is strongly associated with infection with low-risk human papillomaviruses (HPVs), mostly HPV-6 and -11. Immunity to HPVs plays a crucial role in the natural control of various HPV-induced lesions. Large condyloma acuminata are frequently reported in patients with primary (e.g., DOCK8 or SPINK5 deficiencies) and secondary (e.g., AIDS, solid organ transplantation) immune defects. Individuals with extensive anogenital warts, including BLT in particular, should therefore be tested for inherited or acquired immunodeficiency. Research into the genetic basis of unexplained cases is warranted. An understanding of the etiology of BLT would lead to improvements in its management. This review focuses on the role of underlying HPV infections, and human genetic and immunological determinants of BLT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.