Evidence map›Paper›PMID 35562900›Full record

ArticleInternational journal of molecular sciences2022

Epigenetic Deregulation of Protein Tyrosine Kinase 6 Promotes Carcinogenesis of Oral Squamous Cell Carcinoma.

Yi-Ping Hsieh, Ken-Chung Chen, Meng-Yen Chen, Ling-Yu Huang, An-Yu Su, Wei-Fan Chiang, Wen-Tsung Huang, Tze-Ta Huang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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  5. International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yi-Ping HsiehInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Ken-Chung ChenInstitute of Oral Medicine, Department of Dentistry, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Meng-Yen ChenInstitute of Oral Medicine, Department of Dentistry, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Ling-Yu HuangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
An-Yu SuDepartment of Dentistry, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.ORCID 0000-0002-4322-8094
Wei-Fan ChiangChi Mei Medical Center, Liouying, Tainan 72263, Taiwan.
Wen-Tsung HuangChi Mei Medical Center, Liouying, Tainan 72263, Taiwan.
Tze-Ta HuangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
National Cheng Kung University · TWNational Cheng Kung University Hospital · TWChi Mei Medical Center · TWNational Yang Ming Chiao Tung University · TW

Funding

Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University (NCKU), Taiwan; Chi-Mei Medical Center, Liouying CMNCKU10517, CMNCKU10602, and CLFHR10801Ministry of Health and Welfare MOHW107-TDU-B-212-114013, MOHW109-TDU-B-212-134016, MOHW110-TDU-B-212-144013, MOHW111-TDU-B-221-114012Ministry of Science and Technology, Taiwan 109-2314-B-006-013-, 109-2740-B-400-002-, 108-2314-B-006-018-, 106-2314-B-006-016-, and 104-2314-B-006-062-National Cheng Kung University Hospital NCKUH-10902064, NCKUH-10604032, and NCKUH-10406031, NCKUH-11104013-National Health Research Institutes, Taiwan CA-109-PP-18
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral cancers and causes considerable morbidity and mortality. Epigenetic deregulation is a common mechanism underlying carcinogenesis. DNA methylation deregulation is the epigenetic change observed during the transformation of normal cells to precancerous and eventually cancer cells. This study investigated the DNA methylation patterns of

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsAnimalsCarcinogenesisCell Line, TumorDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMiceNeoplasm ProteinsPromoter Regions, GeneticProtein-Tyrosine KinasesRNA, MessengerSquamous Cell Carcinoma of Head and NeckNeoplasm ProteinsProtein-Tyrosine KinasesPTK6 protein, humanRNA, Messengerepigenetic regulationoral squamous cell carcinomaoral squamous cell carcinoma carcinogenesisprotein tyrosine kinase 6 (PTK6)

Identifiers

PMID35562900
PMCPMC9104624
OpenAlexW4224213491

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.