Evidence map›Paper›PMID 35562704›Full record

ArticleJournal of translational medicine2022

Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases.

Miriam Solomon, Vito Foderà, Annette Eva Langkilde, Perry Elliott, Fabrizio Tagliavini, Trevor Forsyth, Oxana Klementieva, Vittorio Bellotti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miriam SolomonDepartment of Philosophy, Temple University, Philadelphia, PA, USA. miriam.solomon@temple.edu.
Vito FoderàDepartment of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Annette Eva LangkildeDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Perry ElliottInstitute of Cardiovascular Science, University College London (UCL), London, UK.
Fabrizio TagliaviniFondazione IRCCS Istituto Neurologico "Carlo Besta" (FINCB), Milan, Italy.
Trevor ForsythLund Institute for Advanced Neutron and X-ray Science (LINXS), 223 70, Lund, Sweden.
Oxana KlementievaLund Institute for Advanced Neutron and X-ray Science (LINXS), 223 70, Lund, Sweden. oxana.klementieva@med.lu.se.ORCID 0000-0003-1782-050X
Vittorio BellottiUniversity College London (UCL), London, UK. v.bellotti@ucl.ac.uk.

Funding

Medical Research Council MR/K000187/1Medical Research Council MR/R016984/1
6 · The paper itself

Abstract

This paper is a report of recommendations for addressing translational challenges in amyloid disease research. They were developed during and following an international online workshop organized by the LINXS Institute of Advanced Neutron and X-Ray Science in March 2021. Key suggestions include improving cross-cultural communication between basic science and clinical research, increasing the influence of scientific societies and journals (vis-à-vis funding agencies and pharmaceutical companies), improving the dissemination of negative results, and strengthening the ethos of science.

Indexed as

Alzheimer’s diseaseAmyloid diseasesComplexityHeterogeneityNegative resultsTranslational medicine

Identifiers

PMID35562704
PMCPMC9102697

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.