Evidence map›Paper›PMID 35562683›Full record

ArticleBMC ophthalmology2022

Detection of superficial and buried optic disc drusen with swept-source optical coherence tomography.

Xiaohong Guo, Yingjie Wu, Yuhong Wu, Hui Liu, Shuai Ming, Hongpei Cui, Ke Fan, Shuyin Li, Bo Lei

Open access · goldAbstract read
In one paragraph

Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Peripapillary hyperreflective ovoid mass-like structure (PHOMS) and optic disc drusen in pediatric pseudo-papilledema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaohong GuoHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.ORCID http://orcid.org/0000-0001-9733-5592
Yingjie WuHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Yuhong WuHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Hui LiuHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Shuai MingHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Hongpei CuiHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Ke FanHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Shuyin LiHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China.
Bo LeiHenan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, 450003, Henan, China. bolei99@126.com.ORCID http://orcid.org/0000-0002-5497-0905
Henan Provincial People's Hospital · CN

Funding

National Natural Science Foundation of China 81770949
6 · The paper itself

Abstract

backgroundTo detect the superficial and buried optic disc drusen (ODD) with swept-source optical coherence tomography (SS-OCT).

methodsRetrospective cross-sectional study. Twenty patients (age 18-74 years) diagnosed with ODD via B-scan ultrasonography were analysed. All patients underwent color fundus photography (CFP), B-scan ultrasonography, fundus autofluorescence (FAF), and SS-OCT. We defined each hyporeflective signal mass of SS-OCT as an ODD, recorded its location and relationship with Bruch's membrane opening (BMO), and other ophthalmic imaging characteristics.

resultsTwenty (33 eyes) patients had 54 ODDs in all, except one eye did not show abnormal optic disc findings on SS-OCT. We classified ODD into three categories: ODD above BMO, ODD across BMO, and ODD below BMO. The ODDs across BMO were the largest, followed by ODDs below BMO, and those above BMO. The location of the ODDs: One (1.9%) was in the border tissue of Elschnig, 6 (11.1%) might span across the lamina cribrosa, 16 (29.6%) were above BMO located in the neuroepithelial layer, 9 (16.7%) spanned across BMO located near the center of the optic disc, 18 (33.3%) were below BMO located near the center of the optic disc, 4 (7.4%) were below BMO located within the optic disc rim. When the anterior margin was ≥ 100 μm from the BMO, clear autofluorescence could be seen.

conclusionMultimodal imaging provided a deeper understanding of ODD. SS-OCT illustrated more details about the relationship between the posterior surface of ODD, BMO and the lamina cribrosa.

Indexed as

Optic Disk DrusenAdolescentAdultAgedBruch MembraneCross-Sectional StudiesHumansMiddle AgedNerve FibersRetrospective StudiesTomography, Optical CoherenceYoung AdultFundus autofluorescenceLamina cribrosaOptic disc drusenSwept-source optical coherence tomography

Identifiers

PMID35562683
PMCPMC9107153
OpenAlexW4280549272

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.