Observational studyBMC pregnancy and childbirth2022
Risk of adverse fetal outcomes following nonobstetric surgery during gestation: a nationwide population-based analysis.
Observational study in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cancer During Pregnancy: Navigating Clinical and Research Challenges.Current oncology (Toronto, Ont.) · 2026Review
- Stent-assisted coiling of a ruptured renal artery aneurysm in a third trimester pregnant patient.Journal of vascular surgery cases and innovative techniques · 2026Article
- Appendectomy During Pregnancy and the Risk of Preterm Birth: A Systematic Review of Contemporary Clinical Studies.Journal of clinical medicine · 2026Review
- The impact of laparoscopic cholecystectomy on pregnancy outcomes in the United States.Surgical endoscopy · 2025Article
- Between guidelines and reality; the complex decision-making of acute cholecystitis in pregnancy.Langenbeck's archives of surgery · 2025Article
- Systematic Review and Critical Appraisal of Cauda Equina Syndrome Management During Pregnancy.Cureus · 2024Review
- Management of an acute intracranial emergency in pregnancy.BMJ case reports · 2024Article
- Maternal diaphragmatic hernia in pregnancy: A systematic review with a treatment algorithm.World journal of clinical cases · 2023Article
- Meckel's Diverticulum as a Cause of Small Bowel Obstruction Complicated with Gangrene in the Third Trimester of Pregnancy: A Case Report.Journal of clinical medicine · 2023Article
- Pregnant patients requiring emergency general surgery: a scoping review of diagnostic and management strategies.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundLiterature suggests that nonobstetric surgery during gestation is associated with a higher risk of spontaneous abortion, prematurity, and a higher cesarean section rate, but the direct impact on fetal outcomes is still unclear. In this study, we aimed to investigate whether nonobstetric surgery during pregnancy is associated with negative fetal outcomes by analysing a nation-wide database in Taiwan.
methodsThis population-based retrospective observational case-control study was based on the linkage of Taiwan's National Health Insurance Research Database, Birth Reporting Database, and Maternal and Child Health Database between 2004 and 2014. For every pregnancy with nonobstetric surgery during gestation, four controls were randomly matched according to maternal age and delivery year. We estimated adjusted odds ratios (aOR) and 95% confidence intervals (CIs) of adverse fetal outcomes with the non-surgery group as the reference. The primary outcomes involved stillbirth, prematurity, low birth weight, low Apgar scores, and neonatal and infant death.
resultsAmong 23,721 identified pregnancies, 4,747 underwent nonobstetric surgery. Pregnancies with nonobstetric surgery had significantly higher risks of prematurity (aOR: 1.46; 95% CI: 1.31-1.62), lower birth weight (aOR: 1.49; 95% CI: 1.33-1.67), Apgar scores < 7 (1 min, aOR: 1.58; 95% CI: 1.33-1.86; 5 min, aOR: 1.34; 95% CI: 1.03-1.74), neonatal death (aOR: 2.01; 95% CI: 1.18-3.42), and infant death (aOR: 1.69; 95% CI: 1.12-2.54) than those without nonobstetric surgery after adjustment for socioeconomic deprivation, hospital level, and other comorbidities. Surgery performed in the third trimester was associated with a significantly increased rate of prematurity (aOR: 1.38; 95% CI: 1.03-1.85), but lower rates of stillbirth (aOR: 0.1; 95% CI: 0.01-0.75) and Apgar score < 7 at the 5
conclusionsPregnancies with nonobstetric surgery during gestation were associated with increased risks of prematurity, low birth weight, low Apgar scores, neonatal and infant death, longer admission, and higher medical expenses than those without surgery. Furthermore, surgery in the third trimester was associated with a higher rate of prematurity than surgery performed in the first trimester.
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