Evidence map›Paper›PMID 35562675›Full record

ArticleClinical proteomics2022

Label-free LC-MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells.

Qian Li, Liyu Zhang, Yuxin Xu

Open access · goldAbstract read
In one paragraph

Article in Clinical proteomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Unveiling the impact of glutathione (GSH) andJournal of gastrointestinal oncology · 2024
    Article
  4. Applications of Intravital Imaging in Cancer Immunotherapy.Bioengineering (Basel, Switzerland) · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Qian LiDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Anhui, 230601, China.
Liyu ZhangDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Anhui, 230601, China.
Yuxin XuDepartment of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, Anhui, 230601, China. xuyuxin1168@sina.com.ORCID http://orcid.org/0000-0001-7138-4265
Anhui Medical University · CN

Funding

Anhui Provincial Key Research and Development Program No. 201904d07020003.
6 · The paper itself

Abstract

backgroundTreatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular meshwork (TM) is regarded as a new treatment for glaucoma; however, the effects do not meet expectations. Exploring the mechanism by which oxidative stress and antioxidant stress occur in TM cells will offer clues to aid the development of new treatments. METHODS AND

resultsIn our study, we cultured TM cells and used H

conclusionsKey proteins and signaling pathways play important roles in the mechanisms of oxidative stress and antioxidant strategies in TM cells. ICAM-1 knockdown can suppress the apoptosis of TM cells induced by H

Indexed as

Label-freeOxidative stressProteomic analysisSODTrabecular meshwork cells

Identifiers

PMID35562675
PMCPMC9107190
OpenAlexW4280620647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.