ArticleCommunications biology2022
Systems-wide analysis revealed shared and unique responses to moderate and acute high temperatures in the green alga Chlamydomonas reinhardtii.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Fragment-level FAIRness: annotating scientific data and its provenance using data fragment selectors.Journal of integrative bioinformatics · 2026Article
- Estimation of chloroplast macromolecular complex copy numbers and subunit stoichiometries during the Chlamydomonas reinhardtii cell cycle.The Plant journal : for cell and molecular biology · 2026Article
- Multiomics studies reveal how ambient temperature changes govern cellular responses of Chlamydomonas.The Plant cell · 2026Article
- Moderate temperature shifts elicit large-scale changes in the physiology and behavior of a green microalga.The Plant cell · 2026Article
- Metabolic Strategies Under Heat Stress in Non-Adapted and High-Temperature-Adapted Lines of a Marine Diatom.Environmental microbiology · 2026Article
- Metacaspases contribute to the cellular response to heat stress in a marine diatom.The New phytologist · 2026Article
- Phosphorus Loading Drives Microalgal Community Changes and Enhances Nutrient Removal in Photobioreactors Treating Synthetic Wastewater.Plants (Basel, Switzerland) · 2026Article
- Integrative multi-omic and phenotypic analysis of open raceway pond production of Monoraphidium minutum 26B-AM reveals distinct stress signatures for scale-up and infection.Biotechnology for biofuels and bioproducts · 2026Article
- Physiological and Molecular Response Mechanisms ofInternational journal of molecular sciences · 2026Article
- Preparation, maintenance and propagation of synchronous cultures of photoactive Chlamydomonas cells.Nature protocols · 2025Review
- Enhanced thermotolerance via overexpression of a stromal ascorbate peroxidase in Nannochloropsis oceanica.Plant cell reports · 2025Article
- Abiotic Stress-Induced Chloroplast and Cytosolic CaPlant, cell & environment · 2025Article
- Modification of Non-photochemical Quenching Pathways in the CbioRxiv : the preprint server for biology · 2025Article
- Coordinated wound responses in a regenerative animal-algal holobiont.Nature communications · 2024Article
- Analysis of Unique Motility of the Unicellular Green AlgaMicromachines · 2024Article
- Thermoprotection by a cell membrane-localized metacaspase in a green alga.The Plant cell · 2024Article
- Temporal classification of short time series data.BMC bioinformatics · 2024Article
- Identification and preliminary characterization of conserved uncharacterized proteins fromPlant direct · 2023Article
- An RNA thermometer in the chloroplast genome of Chlamydomonas facilitates temperature-controlled gene expression.Nucleic acids research · 2023Article
- High-throughput identification of novel heat tolerance genes via genome-wide pooled mutant screens in the model green alga Chlamydomonas reinhardtii.Plant, cell & environment · 2023Article
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Authors and funding
21 authors.
Funding
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Abstract
Different intensities of high temperatures affect the growth of photosynthetic cells in nature. To elucidate the underlying mechanisms, we cultivated the unicellular green alga Chlamydomonas reinhardtii under highly controlled photobioreactor conditions and revealed systems-wide shared and unique responses to 24-hour moderate (35°C) and acute (40°C) high temperatures and subsequent recovery at 25°C. We identified previously overlooked unique elements in response to moderate high temperature. Heat at 35°C transiently arrested the cell cycle followed by partial synchronization, up-regulated transcripts/proteins involved in gluconeogenesis/glyoxylate-cycle for carbon uptake and promoted growth. But 40°C disrupted cell division and growth. Both high temperatures induced photoprotection, while 40°C distorted thylakoid/pyrenoid ultrastructure, affected the carbon concentrating mechanism, and decreased photosynthetic efficiency. We demonstrated increased transcript/protein correlation during both heat treatments and hypothesize reduced post-transcriptional regulation during heat may help efficiently coordinate thermotolerance mechanisms. During recovery after both heat treatments, especially 40°C, transcripts/proteins related to DNA synthesis increased while those involved in photosynthetic light reactions decreased. We propose down-regulating photosynthetic light reactions during DNA replication benefits cell cycle resumption by reducing ROS production. Our results provide potential targets to increase thermotolerance in algae and crops.
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