Evidence map›Paper›PMID 35562385›Full record

ArticleScientific reports2022

Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder.

Cigdem Gelegen, Diana Cash, Katarina Ilic, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jonathan T Brown and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
  6. Article
  7. REM Behavior Disorder: Implications for PD Therapeutics.Current neurology and neuroscience reports · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Cigdem Gelegen *Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), De Crespigny Park, Box 089, London, SE5 8AF, UK.
Diana Cash *Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), De Crespigny Park, Box 089, London, SE5 8AF, UK.
Katarina IlicDepartment of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), De Crespigny Park, Box 089, London, SE5 8AF, UK.
Millie SanderCollege of Medicine and Health, University of Exeter, Exeter, UK.
Eugene KimBRAIN, Department of Neuroimaging, KCL, London, UK.
Camilla SimmonsBRAIN, Department of Neuroimaging, KCL, London, UK.
Michel BernanosBRAIN, Department of Neuroimaging, KCL, London, UK.
Joana LamaInstitute of Psychiatry, Psychology and Neuroscience, Wolfson Centre for Age-Related Diseases, Guy's Campus, KCL, London, UK.
Karen RandallBRAIN, Department of Neuroimaging, KCL, London, UK.
Jonathan T BrownCollege of Medicine and Health, University of Exeter, Exeter, UK.
Svjetlana Kalanj-BognarCroatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.
Samuel CookeBasic and Clinical Neuroscience, IoPPN, KCL, London, UK.
K Ray ChaudhuriKing's College London and Parkinson's Foundation Centre of Excellence, King's College Hospital, London, UK.
Clive BallardCollege of Medicine and Health, University of Exeter, Exeter, UK.
Paul Francis *College of Medicine and Health, University of Exeter, Exeter, UK.
Ivana Rosenzweig *Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), De Crespigny Park, Box 089, London, SE5 8AF, UK. ivana.1.rosenzweig@kcl.ac.uk.
King's College London · GBWellcome Centre for Human Neuroimaging · GBUniversity of Exeter · GBKing's College Hospital NHS Foundation Trust · GBUniversity of Zagreb · HR

Funding

Medical Research Council MR/N026063/1Medical Research Council MR/W006251/1Wellcome Trust 103952/Z/14/ZWellcome Trust 212934/Z/18/Z
6 · The paper itself

Abstract

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.

Indexed as

REM Sleep Behavior DisorderSynucleinopathiesAnimalsHumansMiceProdromal SymptomsSleepSleep, REM

Identifiers

PMID35562385
PMCPMC9105586
OpenAlexW4280513506

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.