Evidence map›Paper›PMID 35562241›Full record

ArticleNeuromuscular disorders : NMD2022

Neuromuscular complications of severe COVID-19 in paediatric patients: Medium-term follow-up.

Daniela Avila-Smirnow, Pamela Céspedes, Felipe Reyes, Jenniffer Angulo, Agustín Cavagnaro, Adriana Wegner

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neuromuscular disorders : NMD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniela Avila-SmirnowUnidad de Neurología Pediátrica, División de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Región Metropolitana 8330077, Chile; Unidad de Neurología, Servicio de Pediatría, Complejo Asistencial Dr. Sótero del Río, Av. Concha y Toro 3459, Puente Alto, Región Metropolitana 8207257, Chile. Electronic address: davila@uc.cl.
Pamela CéspedesUnidad de Paciente Crítico Pediátrico, Servicio de Pediatría, Complejo Asistencial Dr. Sótero del Río, Av. Concha y Toro 3459, Puente Alto, Región Metropolitana 8207257, Chile.
Felipe ReyesUnidad de Infectología Pediátrica, Servicio de Pediatría, Complejo Asistencial Dr. Sótero del Río, Av. Concha y Toro 3459, Puente Alto, Región Metropolitana 8207257, Chile.
Jenniffer AnguloLaboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Departamento de Enfermedades Infecciosas e Inmunología Pediátrica, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins 340, 8331150 Santiago, Chile.
Agustín CavagnaroUnidad de Paciente Crítico Pediátrico, Servicio de Pediatría, Complejo Asistencial Dr. Sótero del Río, Av. Concha y Toro 3459, Puente Alto, Región Metropolitana 8207257, Chile.
Adriana WegnerUnidad de Paciente Crítico Pediátrico, Servicio de Pediatría, Complejo Asistencial Dr. Sótero del Río, Av. Concha y Toro 3459, Puente Alto, Región Metropolitana 8207257, Chile.
Complejo Asistencial Sótero del Río · CLPontificia Universidad Católica de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromuscular complications in paediatric patients with severe coronavirus disease 2019 (COVID-19) are poorly characterised. However, adult patients with severe COVID-19 reportedly present with frequent neuromuscular complications that mainly include critical illness polyneuropathy (CIP), critical illness myopathy (CIM), and focal neuropathies. We examined the records of all paediatric patients with severe COVID-19 who were mechanically ventilated and experienced neuromuscular complications from our single tertiary centre between March 2020 and August 2021. During this period, 4/36 (11%) patients admitted to the paediatric ICU who were mechanically ventilated experienced neuromuscular complications (one CIM, two focal neuropathies, and one CIP associated with plexopathy). In three of them, the gamma genetic variant of SARS-CoV-2 was identified. At the 4-5 month follow-up, three of our patients exhibited slight clinical improvement. We conclude that paediatric patients with severe COVID-19 may present neuromuscular complications similar to adults (11%), and their medium-term prognosis seems unfavourable.

Indexed as

COVID-19Muscular DiseasesPeripheral Nervous System DiseasesPolyneuropathiesAdultChildCritical IllnessFollow-Up StudiesHumansIntensive Care UnitsSARS-CoV-2Brachial plexus neuropathiesCOVID-19Intensive care unitsNeuromuscular manifestationsPeripheral nervous systemSevere acute respiratory syndrome

Identifiers

PMID35562241
PMCPMC8993496
OpenAlexW4226344441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.